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Similarities and interplay between senescent cells and macrophages

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Title: Similarities and interplay between senescent cells and macrophages
Authors: Behmoaras, J
Gil, J
Item Type: Journal Article
Abstract: Senescence is a cellular program that prevents the replication of old, damaged, or cancerous cells. Senescent cells become growth arrested and undergo changes in their morphology, chromatin organization, and metabolism, and produce a bioactive secretome. This secretome, the senescence-associated secretory phenotype (SASP), mediates many of the pathophysiological effects associated with senescent cells, for example, recruiting and activating immune cells such as macrophages. The relation between senescent cells and macrophages is intriguing: senescent cells recruit macrophages, can induce them to undergo senescence, or can influence their polarization. Senescent cells and macrophages share multiple phenotypic characteristics; both have a high secretory status, increased lysosome numbers, or the ability to activate the inflammasome. Senescent cells accumulate during aging and disease, and killing them results in widespread benefits. Here we discuss similarities between senescent cells and macrophages and interpret the latest developments in macrophage biology to understand the molecular mechanisms of cellular senescence. We describe evidence and effects of senescence in macrophages and speculate on the ontogeny of the senescent-like state in macrophages. Finally, we examine the macrophage–senescent cell interplay and its impact on macrophage effector functions during inflammatory conditions and in the tumor microenvironment.
Issue Date: 1-Feb-2021
Date of Acceptance: 1-Dec-2020
URI: http://hdl.handle.net/10044/1/86495
DOI: 10.1083/jcb.202010162
ISSN: 0021-9525
Publisher: Rockefeller University Press
Journal / Book Title: The Journal of Cell Biology
Volume: 220
Issue: 2
Copyright Statement: © 2020 Behmoaras and Gil. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: MR/N01121X/1
MR/V027638/1
Keywords: Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status: Published
Article Number: ARTN e202010162
Online Publication Date: 2020-12-23
Appears in Collections:Department of Immunology and Inflammation
Institute of Clinical Sciences



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