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Metabolic signatures of gestational weight gain and postpartum weight loss in a lifestyle intervention study of overweight and obese women

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Title: Metabolic signatures of gestational weight gain and postpartum weight loss in a lifestyle intervention study of overweight and obese women
Authors: Lau, CH
Taylor-Bateman, V
Vorkas, PA
Gomes Da Graca, G
Vu, T-H
Hou, L
Chekmeneva, E
Ebbels, T
Chan, Q
Van Horn, L
Holmes, E
Item Type: Journal Article
Abstract: BACKGROUND: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy could potentially be applied to elucidate the molecular basis of the adverse effects of gestational weight gain (GWG) and postpartum weight loss (WL) on future risks for cardiovascular disease (CVD) and other chronic diseases. METHODS: Biofluid samples were collected from 114 ethnically diverse pregnant women with body mass index (BMI) between 25 and 40 kg/m2 from Chicago (US), as part of a randomized lifestyle intervention trial (Maternal Offspring Metabolics: Family Intervention Trial; NCT01631747). At 15 weeks, 35 weeks of gestation, and at 1 year postpartum, the blood plasma lipidome and metabolic profile of urine samples were analyzed by liquid chromatography mass spectrometry (LC-MS) and 1H nuclear magnetic resonance spectroscopy (1H NMR) respectively. RESULTS: Urinary 4-deoxyerythronic acid and 4-deoxythreonic acid were found to be positively correlated to BMI. Seventeen plasma lipids were found to be associated with GWG and 16 lipids were found to be associated with WL, which included phosphatidylinositols (PI), phosphatidylcholines (PC), lysophospholipids (lyso-), sphingomyelins (SM) and ether phosphatidylcholine (PC-O). Three phospholipids found to be positively associated with GWG all contained palmitate side-chains, and amongst the 14 lipids that were negatively associated with GWG, seven were PC-O. Six of eight lipids found to be negatively associated with WL contained an 18:2 fatty acid side-chain. CONCLUSIONS: Maternal obesity was associated with characteristic urine and plasma metabolic phenotypes, and phospholipid profile was found to be associated with both GWG and postpartum WL in metabolically healthy pregnant women with overweight/obesity. Postpartum WL may be linked to the reduction in the intake of linoleic acid/conjugated linoleic acid food sources in our study population.
Issue Date: 4-Dec-2020
Date of Acceptance: 1-Dec-2020
URI: http://hdl.handle.net/10044/1/86030
DOI: 10.3390/metabo10120498
ISSN: 2218-1989
Publisher: MDPI AG
Journal / Book Title: Metabolites
Volume: 10
Issue: 12
Copyright Statement: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
National Institutes of Health
Japan Society for the Promotion of Science
Funder's Grant Number: RDA27
60045948 ICSTM
20171002 & 20180913
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
metabolic phenotyping
metabolomics
blood lipids
LC-MS
NMR
gestational weight gain
lifestyle intervention
EARLY-PREGNANCY
CHILDREN
IDENTIFICATION
ASSOCIATION
PROFILE
ACID
BMI
LC-MS
NMR
blood lipids
gestational weight gain
lifestyle intervention
metabolic phenotyping
metabolomics
0301 Analytical Chemistry
0601 Biochemistry and Cell Biology
1103 Clinical Sciences
Publication Status: Published
Online Publication Date: 2020-12-04
Appears in Collections:Department of Metabolism, Digestion and Reproduction
School of Public Health



This item is licensed under a Creative Commons License Creative Commons