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The effect of lower limb revascularization on flow, perfusion, and systemic endothelial function: a systematic review.

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Title: The effect of lower limb revascularization on flow, perfusion, and systemic endothelial function: a systematic review.
Authors: Normahani, P
Khosravi, S
Sounderajah, V
Aslam, M
Standfield, NJ
Jaffer, U
Item Type: Journal Article
Abstract: Peripheral arterial disease (PAD) is associated with reduced lower limb blood flow and tissue perfusion. The consequent reduction in vessel wall shear stress as well as ischemia-reperfusion injury has also been associated with systemic endothelial dysfunction and inflammation. We aimed to explore the impact of lower limb revascularization on (1) lower limb blood flow, (2) tissue perfusion, and (3) systemic endothelial function. We performed a systematic literature search using the MEDLINE, Embase, and Web of Science databases. Eligible studies measured changes in lower limb blood flow, perfusion, or systemic endothelial function following revascularization for the treatment of symptomatic PAD. We found 19 eligible studies, which were limited by considerable heterogeneity. Current evidence suggests that revascularization has a positive effect on flow, perfusion, and systemic endothelial dysfunction. Any changes may take a number of weeks to become apparent. There is a need for well-designed studies to explore the association between flow, perfusion, and endothelial dysfunction.
Issue Date: 1-Mar-2021
Date of Acceptance: 1-Nov-2020
URI: http://hdl.handle.net/10044/1/85781
DOI: 10.1177/0003319720969543
ISSN: 0003-3197
Publisher: SAGE Publications
Start Page: 210
End Page: 220
Journal / Book Title: Angiology
Volume: 72
Issue: 3
Copyright Statement: © The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Sponsor/Funder: National Institute of Health Research
Keywords: Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
systemic endothelial function
flow
perfusion
revascularization
peripheral arterial disease
flow
perfusion
peripheral arterial disease
revascularization
systemic endothelial function
Aged
Aged, 80 and over
Endothelium, Vascular
Endovascular Procedures
Female
Humans
Intermittent Claudication
Ischemia
Lower Extremity
Male
Middle Aged
Observational Studies as Topic
Peripheral Arterial Disease
Recovery of Function
Regional Blood Flow
Reperfusion Injury
Risk Factors
Treatment Outcome
Vascular Surgical Procedures
Lower Extremity
Endothelium, Vascular
Humans
Intermittent Claudication
Ischemia
Reperfusion Injury
Treatment Outcome
Vascular Surgical Procedures
Risk Factors
Recovery of Function
Regional Blood Flow
Aged
Aged, 80 and over
Middle Aged
Female
Male
Endovascular Procedures
Peripheral Arterial Disease
Observational Studies as Topic
flow
perfusion
peripheral arterial disease
revascularization
systemic endothelial function
Cardiovascular System & Hematology
1103 Clinical Sciences
Publication Status: Published
Conference Place: United States
Online Publication Date: 2020-11-04
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons