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Understanding the cumulative risk of maternal prenatal biopsychosocial factors on birth weight: a DynaHEALTH study on two birth cohorts

Title: Understanding the cumulative risk of maternal prenatal biopsychosocial factors on birth weight: a DynaHEALTH study on two birth cohorts
Authors: Parmar, P
Lowry, E
Vehmeijer, F
El Marroun, H
Lewin, A
Tolvanen, M
Tzala, E
Ala-Mursula, L
Herzig, K-H
Miettunen, J
Prokopenko, I
Rautio, N
Jaddoe, VWV
Jarvelin, M-R
Felix, J
Sebert, S
Item Type: Journal Article
Abstract: Background There are various maternal prenatal biopsychosocial (BPS) predictors of birth weight, making it difficult to quantify their cumulative relationship. Methods We studied two birth cohorts: Northern Finland Birth Cohort 1986 (NFBC1986) born in 1985–1986 and the Generation R Study (from the Netherlands) born in 2002–2006. In NFBC1986, we selected variables depicting BPS exposure in association with birth weight and performed factor analysis to derive latent constructs representing the relationship between these variables. In Generation R, the same factors were generated weighted by loadings of NFBC1986. Factor scores from each factor were then allocated into tertiles and added together to calculate a cumulative BPS score. In all cases, we used regression analyses to explore the relationship with birth weight corrected for sex and gestational age and additionally adjusted for other factors. Results Factor analysis supported a four-factor structure, labelled closely to represent their characteristics as ‘Factor1-BMI’ (body mass index), ‘Factor2-DBP’ (diastolic blood pressure), ‘Factor3-Socioeconomic-Obstetric-Profile’ and ‘Factor4-Parental-Lifestyle’. In both cohorts, ‘Factor1-BMI’ was positively associated with birth weight, whereas other factors showed negative association. ‘Factor3-Socioeconomic-Obstetric-Profile’ and ‘Factor4-Parental-Lifestyle’ had the greatest effect size, explaining 30% of the variation in birth weight. Associations of the factors with birth weight were largely driven by ‘Factor1-BMI’. Graded decrease in birth weight was observed with increasing cumulative BPS score, jointly evaluating four factors in both cohorts. Conclusion Our study is a proof of concept for maternal prenatal BPS hypothesis, highlighting the components snowball effect on birth weight in two different European birth cohorts.
Issue Date: 1-Nov-2020
Date of Acceptance: 30-May-2020
URI: http://hdl.handle.net/10044/1/85447
DOI: 10.1136/jech-2019-213154
ISSN: 0143-005X
Publisher: BMJ Publishing Group
Start Page: 933
End Page: 941
Journal / Book Title: Journal of Epidemiology and Community Health
Volume: 74
Issue: 11
Copyright Statement: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Sponsor/Funder: UNIVERSITY OF OULU
Commission of the European Communities
Funder's Grant Number: Nil
874739
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Ageing
Diabetes
Disability
Child health
Maternal health
Birth defects
Cardiovascular disease
Birth weight
Epidemiology of chronic non communicable diseases
Life course epidemiology
Cohort studies
Biostatistics
BODY-MASS INDEX
GESTATIONAL-AGE
PREGNANCY
HEALTH
DETERMINANTS
OBESITY
GROWTH
UPDATE
LENGTH
Ageing
Biostatistics
Birth defects
Birth weight
Cardiovascular disease
Child health
Cohort studies
Diabetes
Disability
Epidemiology of chronic non communicable diseases
Life course epidemiology
Maternal health
Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Ageing
Diabetes
Disability
Child health
Maternal health
Birth defects
Cardiovascular disease
Birth weight
Epidemiology of chronic non communicable diseases
Life course epidemiology
Cohort studies
Biostatistics
BODY-MASS INDEX
GESTATIONAL-AGE
PREGNANCY
HEALTH
DETERMINANTS
OBESITY
GROWTH
UPDATE
LENGTH
Epidemiology
1117 Public Health and Health Services
1604 Human Geography
Publication Status: Published
Online Publication Date: 2020-06-24
Appears in Collections:School of Public Health



This item is licensed under a Creative Commons License Creative Commons