4
IRUS Total
Downloads

Plant foods, dietary fibre and risk of ischaemic heart disease in the European prospective investigation into cancer and nutrition (EPIC) cohort

File Description SizeFormat 
dyaa155.pdfPublished version662.46 kBAdobe PDFView/Open
Title: Plant foods, dietary fibre and risk of ischaemic heart disease in the European prospective investigation into cancer and nutrition (EPIC) cohort
Authors: Perez-Cornago, A
Crowe, FL
Appleby, PN
Bradbury, KE
Wood, AM
Jakobsen, MU
Johnson, L
Sacerdote, C
Steur, M
Weiderpass, E
Würtz, AML
Kühn, T
Katzke, V
Trichopoulou, A
Karakatsani, A
La Vecchia, C
Masala, G
Tumino, R
Panico, S
Sluijs, I
Skeie, G
Imaz, L
Petrova, D
Quirós, JR
Yohar, SMC
Jakszyn, P
Melander, O
Sonestedt, E
Andersson, J
Wennberg, M
Aune, D
Riboli, E
Schulze, MB
Di Angelantonio, E
Wareham, NJ
Danesh, J
Forouhi, NG
Butterworth, AS
Key, TJ
Item Type: Journal Article
Abstract: BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. RESULTS: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. CONCLUSIONS: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.
Issue Date: Feb-2021
Date of Acceptance: 27-Jul-2020
URI: http://hdl.handle.net/10044/1/85086
DOI: 10.1093/ije/dyaa155
ISSN: 0300-5771
Publisher: Oxford University Press (OUP)
Start Page: 212
End Page: 222
Journal / Book Title: International Journal of Epidemiology
Volume: 50
Issue: 1
Copyright Statement: © The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permitsunrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
Keywords: Fruit
coronary heart disease
legumes
nuts
seeds
vegetables
Fruit
coronary heart disease
legumes
nuts
seeds
vegetables
0104 Statistics
1117 Public Health and Health Services
Epidemiology
Publication Status: Published
Conference Place: England
Online Publication Date: 2020-11-27
Appears in Collections:Faculty of Medicine
School of Public Health



This item is licensed under a Creative Commons License Creative Commons