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The role of circular RNAs in pancreatic ductal adenocarcinoma and biliary-tract cancers

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Title: The role of circular RNAs in pancreatic ductal adenocarcinoma and biliary-tract cancers
Authors: Limb, C
Liu, D
Veno, M
Rees, E
Krell, J
Bagwan, I
Giovannetti, E
Pandha, H
Strobel, O
Rockall, T
Frampton, A
Item Type: Journal Article
Abstract: Pancreatic Ductal Adenocarcinoma (PDAC) and biliary-tract cancers (BTC) often present at a late stage, and consequently patients have poor survival-outcomes. Circular RNAs (circRNAs) are non-coding RNA molecules whose role in tumourigenesis has recently been realised. They are stable, conserved and abundant, with tissue-specific expression profiles. Therefore, significant interest has arisen in their use as potential biomarkers for PDAC and BTC. High-throughput methods and more advanced bioinformatic techniques have enabled better profiling and progressed our understanding of how circRNAs may function in the competing endogenous RNA (ceRNA) network to influence the transcriptome in these cancers. Therefore, the aim of this systematic review was to describe the roles of circRNAs in PDAC and BTC, their potential as biomarkers, and their function in the wider ceRNA network in regulating microRNAs and the transcriptome. Medline, Embase, Scopus and PubMed were systematically reviewed to identify all the studies addressing circRNAs in PDAC and BTC. A total of 32 articles were included: 22 considering PDAC, 7 for Cholangiocarcinoma (CCA) and 3 for Gallbladder Cancer (GBC). There were no studies investigating Ampullary Cancer. Dysregulated circRNA expression was associated with features of malignancy in vitro, in vivo, and ex vivo. Overall, there have been very few PDAC and BTC tissues profiled for circRNA signatures. Therefore, whilst the current studies have demonstrated some of their functions in these cancers, further work is required to elucidate their potential role as cancer biomarkers in tissue, biofluids and biopsies.
Issue Date: 4-Nov-2020
Date of Acceptance: 26-Oct-2020
URI: http://hdl.handle.net/10044/1/85073
DOI: 10.3390/cancers12113250
ISSN: 2072-6694
Publisher: MDPI AG
Journal / Book Title: Cancers
Volume: 12
Issue: 11
Copyright Statement: ©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: J P Moulton Charitable Foundation
Funder's Grant Number: N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
biomarker
pancreatic cancer
pancreatic ductal adenocarcinoma
biliary tract cancer
circular RNA
circrna
circRNAs
DIFFERENTIALLY-EXPRESSED CIRCRNAS
MESSENGER-RNA
PROGNOSTIC BIOMARKER
CERNA HYPOTHESIS
TRANSCRIPTION
GEMCITABINE
DEGRADATION
BIOGENESIS
RESISTANCE
MICRORNAS
biliary tract cancer
biomarker
circRNAs
circrna
circular RNA
pancreatic cancer
pancreatic ductal adenocarcinoma
1112 Oncology and Carcinogenesis
Publication Status: Published
Article Number: ARTN 3250
Appears in Collections:Department of Surgery and Cancer



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