Three distinct hematological malignancies from a single germ cell tumor: a case report.

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Title: Three distinct hematological malignancies from a single germ cell tumor: a case report.
Authors: Spencer Chapman, M
May, PC
Olavarria, E
Nadal Melsio, E
Item Type: Journal Article
Abstract: BACKGROUND: The association between non seminomatous germ cell tumors (GCTs) and hematological malignancies of rare lineage has been described in the literature. In some of these cases there is evidence that the leukemia derives from a pluripotent primitive clone present in the original germ cell tumor. CASE PRESENTATION: We present a highly unusual case of a 23-year-old man of South Asian origin with a history of Klinefelter's syndrome who initially developed mediastinal non seminomatous GCT. Following treatment with surgery and standard chemotherapy he went on to develop three different hematological malignancies of distinct lineages in sequential fashion over a short time period. Despite treatment with multiple intensive chemotherapy regimens and a matched unrelated donor allogeneic stem cell transplant, he died 41 months after initial diagnosis of his GCT and 10 months after the first diagnosis of hematological malignancy. CONCLUSIONS: This is an extreme case that highlights the pluripotency and aggressiveness of these GCT-derived hematological malignancies, and the need for novel therapeutic approaches.
Issue Date: 17-Nov-2020
Date of Acceptance: 14-Oct-2020
URI: http://hdl.handle.net/10044/1/84636
DOI: 10.1186/s13256-020-02558-8
ISSN: 1752-1947
Publisher: BioMed Central
Journal / Book Title: Journal of Medical Case Reports
Volume: 14
Issue: 222
Copyright Statement: © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Keywords: AML
Acute myeloid leukemia
Burkitt’s lymphoma
Clonal evolution
Germ cell tumor
Klinefelter’s syndrome
Malignant transformation
Mediastinal non seminomatous germ cell tumor
Teratoma
AML
Acute myeloid leukemia
Burkitt’s lymphoma
Clonal evolution
Germ cell tumor
Klinefelter’s syndrome
Malignant transformation
Mediastinal non seminomatous germ cell tumor
Teratoma
1199 Other Medical and Health Sciences
General & Internal Medicine
Publication Status: Published
Conference Place: England
Open Access location: https://doi.org/10.1186/s13256-020-02558-8
Online Publication Date: 2020-11-17
Appears in Collections:Department of Immunology and Inflammation



This item is licensed under a Creative Commons License Creative Commons