79
IRUS Total
Downloads
  Altmetric

Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial

File Description SizeFormat 
j.jalz.2017.09.006.pdfPublished version309.37 kBAdobe PDFView/Open
Title: Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
Authors: Rosenberg, A
Ngandu, T
Rusanen, M
Antikainen, R
Backman, L
Havulinna, S
Hanninen, T
Laatikainen, T
Lehtisalo, J
Levalahti, E
Lindstrom, J
Paajanen, T
Peltonen, M
Soininen, H
Stigsdotter-Neely, A
Strandberg, T
Tuomilehto, J
Solomon, A
Kivipelto, M
Item Type: Journal Article
Abstract: Introduction The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Methods The FINGER recruited 1260 people from the general Finnish population (60–77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. Results Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini–Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05). Conclusions The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.
Issue Date: 1-Mar-2018
Date of Acceptance: 12-Oct-2017
URI: http://hdl.handle.net/10044/1/84542
DOI: 10.1016/j.jalz.2017.09.006
ISSN: 1552-5260
Publisher: Wiley
Start Page: 263
End Page: 270
Journal / Book Title: Alzheimers & Dementia
Volume: 14
Issue: 3
Copyright Statement: © 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Prevention
Cognitive impairment
Dementia
Alzheimer's disease
Multidomain
Lifestyle
Intervention
Randomized controlled trial
FINNISH GERIATRIC INTERVENTION
RANDOMIZED CONTROLLED-TRIAL
CORONARY-HEART-DISEASE
ALZHEIMERS-DISEASE
OLDER-ADULTS
PRIMARY PREVENTION
EXERCISE
IMPAIRMENT
COMPLAINTS
PROTOCOL
Alzheimer's disease
Cognitive impairment
Dementia
Intervention
Lifestyle
Multidomain
Prevention
Randomized controlled trial
Aged
Cardiovascular Diseases
Cognition
Cognitive Behavioral Therapy
Cognitive Dysfunction
Dementia
Exercise Therapy
Female
Healthy Lifestyle
Humans
Male
Middle Aged
Risk Factors
Socioeconomic Factors
Treatment Outcome
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Prevention
Cognitive impairment
Dementia
Alzheimer's disease
Multidomain
Lifestyle
Intervention
Randomized controlled trial
FINNISH GERIATRIC INTERVENTION
RANDOMIZED CONTROLLED-TRIAL
CORONARY-HEART-DISEASE
ALZHEIMERS-DISEASE
OLDER-ADULTS
PRIMARY PREVENTION
EXERCISE
IMPAIRMENT
COMPLAINTS
PROTOCOL
Geriatrics
1103 Clinical Sciences
1109 Neurosciences
Publication Status: Published
Online Publication Date: 2017-10-19
Appears in Collections:School of Public Health



This item is licensed under a Creative Commons License Creative Commons