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Fulleropyrrolidine-functionalized ceria nanoparticles as a tethered dual nanosystem with improved antioxidant properties

Title: Fulleropyrrolidine-functionalized ceria nanoparticles as a tethered dual nanosystem with improved antioxidant properties
Authors: Pinna, A
Cali, E
Kerherve, G
Galleri, G
Maggini, M
Innocenzi, P
Malfatti, L
Item Type: Journal Article
Abstract: Dual-tethered nanosystems which combine different properties at the nano scale represent a new fascinating frontier of research. In the present work, we present an example of a dual nanosystem designed to enhance the radical scavenging performances. Fulleropyrrolidine has been bonded to cerium oxide nanoparticles (nanoceria) to form a dual tethered system. Fulleropyrrolidine, bearing a silyl-alkoxide group, has been chemically bonded to the nanoceria surface, providing unprecedented antioxidant activity. This effect has been evaluated using an L929 mouse fibroblast cell line exposed to UV light. The fulleropyrrolidine molecules tethered to nanoceria enhance the radical scavenging properties of the oxide. At the same time, fulleropyrrolidine mitigates the potential toxicity of nanoceria at high doses. On the other hand, cerium oxide nanoparticles provide a strong hydrophilicity to the dual nanosystem, ensuring the administration in a cellular environment and preventing macroscopic aggregation of fulleropyrrolidine. The rational assembly of two different components in one nanosystem appears as a promising route for the development of “smarter” medical and cosmetic devices.
Issue Date: 1-Jun-2020
Date of Acceptance: 12-Apr-2020
URI: http://hdl.handle.net/10044/1/84517
DOI: 10.1039/d0na00048e
ISSN: 2516-0230
Publisher: Royal Society of Chemistry
Start Page: 2387
End Page: 2396
Journal / Book Title: Nanoscale Advances
Volume: 2
Issue: 6
Copyright Statement: © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence http://creativecommons.org/licenses/by-nc/3.0/.
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
OXIDE NANOPARTICLES
C-60 FULLERENE
NANOCERIA
MODULATION
OXYGEN
FILMS
SPECTROSCOPY
FABRICATION
REDUCTION
SPECTRA
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
OXIDE NANOPARTICLES
C-60 FULLERENE
NANOCERIA
MODULATION
OXYGEN
FILMS
SPECTROSCOPY
FABRICATION
REDUCTION
SPECTRA
Publication Status: Published
Online Publication Date: 2020-04-13
Appears in Collections:Materials



This item is licensed under a Creative Commons License Creative Commons