Genetic diversity of the African malaria vector Anopheles gambiae

Title: Genetic diversity of the African malaria vector Anopheles gambiae
Authors: Miles, A
Harding, NJ
Botta, G
Clarkson, CS
Antao, T
Kozak, K
Schrider, DR
Kern, AD
Redmond, S
Sharakhov, I
Pearson, RD
Bergey, C
Fontaine, MC
Donnelly, MJ
Lawniczak, MKN
Kwiatkowski, DP
Ayala, D
Besensky, NJ
Burt, A
Caputo, B
Della Torre, A
Fontaine, MC
Godfrey, HCJ
Hahn, MW
Midega, J
Neafsey, DE
O'Loughlin, S
Pinto, J
Riehle, MM
Vernick, KD
Weetman, D
Wilding, CS
White, BJ
Troco, AD
Diabate, A
Costantini, C
Rohatgi, KR
Besansky, NJ
Elissa, N
Coulibaly, B
Dinis, J
Midegal, J
Mbogo, C
Bejon, P
Mawejje, HD
Stalker, J
Rockett, K
Drury, E
Mead, D
Jeffreys, A
Hubbard, C
Rowlands, K
Isaacs, AT
Jyothi, D
Malangone, C
Vauterin, P
Jeffery, B
Wright, I
Hart, L
Kluczyriski, K
Cornelius, V
MacInnisn, B
Henrichs, C
Giacomantonio, R
Item Type: Journal Article
Abstract: The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
Issue Date: 7-Dec-2017
Date of Acceptance: 1-Nov-2017
URI: http://hdl.handle.net/10044/1/84173
DOI: 10.1038/nature24995
ISSN: 0028-0836
Publisher: Nature Publishing Group
Start Page: 96
End Page: 100
Journal / Book Title: Nature
Volume: 552
Issue: 7683
Copyright Statement: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Sponsor/Funder: The Royal Society
Bill & Melinda Gates Foundation
Silicon Valley Community Foundation
Medical Research Council (MRC)
Funder's Grant Number: WM110082
OPP1141988
N/A
G1100339
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
POPULATION-STRUCTURE
DROSOPHILA-MELANOGASTER
INCIPIENT SPECIATION
POSITIVE SELECTION
MOSQUITO
FLOW
INTROGRESSION
DIVERGENCE
RESISTANCE
CULICIDAE
Africa
Animals
Anopheles
Female
Gene Drive Technology
Gene Flow
Genetic Variation
Genome, Insect
Insecticide Resistance
Malaria
Male
Mosquito Control
Mosquito Vectors
Polymorphism, Single Nucleotide
Population Density
X Chromosome
Anopheles gambiae 1000 Genomes Consortium
Data analysis group
Partner working group
Sample collections—Angola:
Burkina Faso:
Cameroon:
Gabon:
Guinea:
Guinea-Bissau:
Kenya:
Uganda:
Crosses:
Sequencing and data production
Web application development
Project coordination
X Chromosome
Animals
Anopheles
Malaria
Population Density
Mosquito Control
Insecticide Resistance
Polymorphism, Single Nucleotide
Africa
Female
Male
Genome, Insect
Gene Flow
Genetic Variation
Mosquito Vectors
Gene Drive Technology
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
POPULATION-STRUCTURE
DROSOPHILA-MELANOGASTER
INCIPIENT SPECIATION
POSITIVE SELECTION
MOSQUITO
FLOW
INTROGRESSION
DIVERGENCE
RESISTANCE
CULICIDAE
General Science & Technology
Publication Status: Published
Open Access location: http://researchonline.ljmu.ac.uk/id/eprint/7775/
Online Publication Date: 2017-11-29
Appears in Collections:Faculty of Natural Sciences