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G protein-coupled estrogen receptor regulates actin cytoskeleton dynamics to impair cell polarization

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Title: G protein-coupled estrogen receptor regulates actin cytoskeleton dynamics to impair cell polarization
Authors: Lachowski, D
Cortes Lopez, J
Matellan, C
Rice, A
Lee, DA
Thorpe, S
Del Rio Hernandez, A
Item Type: Journal Article
Abstract: Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens. Here, we demonstrate an unidentified role of GPER as a cellular mechanoregulator. G protein-coupled estrogen receptor signaling controls the assembly of stress fibers, the dynamics of the associated focal adhesions, and cell polarization via RhoA GTPase (RhoA). G protein-coupled estrogen receptor activation inhibits F-actin polymerization and subsequently triggers a negative feedback that transcriptionally suppresses the expression of monomeric G-actin. Given the broad expression of GPER and the range of cytoskeletal changes modulated by this receptor, our findings position GPER as a key player in mechanotransduction.
Issue Date: 22-Oct-2020
Date of Acceptance: 24-Sep-2020
URI: http://hdl.handle.net/10044/1/83907
DOI: 10.3389/fcell.2020.592628
ISSN: 2296-634X
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Cell and Developmental Biology
Volume: 8
Copyright Statement: © 2020 Lachowski, Cortes, Matellan, Rice, Lee, Thorpe and del Río Hernández. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 282051
Publication Status: Published
Article Number: ARTN 592628
Appears in Collections:Bioengineering



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