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Theory of neuronal perturbome in cortical networks.

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Title: Theory of neuronal perturbome in cortical networks.
Authors: Sadeh, S
Clopath, C
Item Type: Journal Article
Abstract: To unravel the functional properties of the brain, we need to untangle how neurons interact with each other and coordinate in large-scale recurrent networks. One way to address this question is to measure the functional influence of individual neurons on each other by perturbing them in vivo. Application of such single-neuron perturbations in mouse visual cortex has recently revealed feature-specific suppression between excitatory neurons, despite the presence of highly specific excitatory connectivity, which was deemed to underlie feature-specific amplification. Here, we studied which connectivity profiles are consistent with these seemingly contradictory observations, by modeling the effect of single-neuron perturbations in large-scale neuronal networks. Our numerical simulations and mathematical analysis revealed that, contrary to the prima facie assumption, neither inhibition dominance nor broad inhibition alone were sufficient to explain the experimental findings; instead, strong and functionally specific excitatory-inhibitory connectivity was necessary, consistent with recent findings in the primary visual cortex of rodents. Such networks had a higher capacity to encode and decode natural images, and this was accompanied by the emergence of response gain nonlinearities at the population level. Our study provides a general computational framework to investigate how single-neuron perturbations are linked to cortical connectivity and sensory coding and paves the road to map the perturbome of neuronal networks in future studies.
Issue Date: 27-Oct-2020
Date of Acceptance: 1-Oct-2020
URI: http://hdl.handle.net/10044/1/83818
DOI: 10.1073/pnas.2004568117
ISSN: 0027-8424
Publisher: National Academy of Sciences
Start Page: 26966
End Page: 26976
Journal / Book Title: Proceedings of the National Academy of Sciences of USA
Volume: 117
Issue: 43
Copyright Statement: © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
Sponsor/Funder: Wellcome Trust
Simons Foundation
Engineering & Physical Science Research Council (EPSRC)
Biotechnology and Biological Sciences Research Cou
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: 200790/Z/16/Z
Award ID:564408
EP/R035806/1
ORCA 64155 (BB/N013956/1)
BB/P018785/1
Keywords: cortical connectivity
neuronal perturbation
perturbome
sensory coding
visual cortex
cortical connectivity
neuronal perturbation
perturbome
sensory coding
visual cortex
Publication Status: Published
Conference Place: United States
Online Publication Date: 2020-10-14
Appears in Collections:Bioengineering



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