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3D late gadolinium enhancement cardiovascular magnetic resonance predicts inducibility of ventricular tachycardia in adults with repaired tetralogy of Fallot

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Title: 3D late gadolinium enhancement cardiovascular magnetic resonance predicts inducibility of ventricular tachycardia in adults with repaired tetralogy of Fallot
Authors: Ghonim, S
Ernst, S
Keegan, J
Giannakidis, A
Spadotto, V
Voges, I
Smith, G
Boutsikou, M
Montanaro, C
Wong, T
Ho, SY
McCarthy, K
Shore, D
Dimopoulos, K
Uebing, A
Swan, L
Li, W
Pennell, D
Gatzoulis, M
Babu-Narayan, S
Item Type: Journal Article
Abstract: Background - Adults with repaired tetralogy of Fallot (rTOF) die prematurely from ventricular tachycardia (VT) and sudden cardiac death. Inducible VT predicts mortality. Ventricular scar, the key substrate for VT, can be non-invasively defined with late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) but whether this relates to inducible VT is unknown. Methods - Sixty-nine consecutive rTOF patients (43 male, mean 40{plus minus}15 years) clinically scheduled for invasive programmed VT-stimulation were prospectively recruited for prior 3D LGE CMR. Ventricular LGE was segmented and merged with reconstructed cardiac chambers and LGE volume measured. Results - VT was induced in 22(31%) patients. Univariable predictors of inducible VT included increased RV LGE (OR 1.15;p=0.001 per cm3), increased non-apical vent LV LGE (OR 1.09;p=0.008 per cm3), older age (OR 1.6;p=0.01 per decile), QRS duration ≥180ms (OR 3.5;p=0.02), history of non-sustained VT (OR 3.5; p=0.02) and previous clinical sustained VT (OR 12.8;p=0.003); only prior sustained VT (OR 8.02;p=0.02) remained independent in bivariable analyses after controlling for RV LGE volume (OR 1.14;p=0.003). An RV LGE volume of 25cm3 had 72% sensitivity and 81% specificity for predicting inducible VT (AUC 0.81;p<0.001). At the extreme cutoffs for 'ruling-out' and 'ruling-in' inducible VT, RV LGE >10cm3 was 100% sensitive and >36cm3 was 100% specific for predicting inducible VT. Conclusions - 3D LGE CMR-defined scar burden is independently associated with inducible VT and may help refine patient selection for programmed VT-stimulation when applied to an at least intermediate clinical risk cohort.
Issue Date: Nov-2020
Date of Acceptance: 14-Sep-2020
URI: http://hdl.handle.net/10044/1/83626
DOI: 10.1161/CIRCEP.119.008321
ISSN: 1941-3084
Publisher: Lippincott, Williams & Wilkins
Start Page: 1331
End Page: 1341
Journal / Book Title: Circulation: Arrhythmia and Electrophysiology
Volume: 13
Issue: 11
Copyright Statement: © 2020 American Heart Association, Inc.
Sponsor/Funder: British Heart Foundation
British Heart Foundation
Funder's Grant Number: FS/11/38/28864
EX/18/1/34296
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
gadolinium
magnetic resonance imaging
myocardium
tetralogy of Fallot
ventricular tachycardia
CONGENITAL HEART-DISEASE
MYOCARDIAL FIBROSIS
DEATH
SCAR
STIMULATION
ARRHYTHMIAS
MANAGEMENT
ABLATION
OUTCOMES
MARKERS
gadolinium
magnetic resonance imaging
myocardium
tetralogy of Fallot
ventricular tachycardia
Cardiovascular System & Hematology
1102 Cardiorespiratory Medicine and Haematology
1103 Clinical Sciences
1116 Medical Physiology
Publication Status: Published
Online Publication Date: 2020-10-06
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine