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3D late gadolinium enhancement cardiovascular magnetic resonance predicts inducibility of ventricular tachycardia in adults with repaired tetralogy of Fallot
File | Description | Size | Format | |
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Clean copy manuscript _RV LGE predicts VT inducibility__.doc | Accepted version | 10.34 MB | Microsoft Word | View/Open |
Supplemental material.pdf | Supporting information | 288.11 kB | Adobe PDF | View/Open |
Title: | 3D late gadolinium enhancement cardiovascular magnetic resonance predicts inducibility of ventricular tachycardia in adults with repaired tetralogy of Fallot |
Authors: | Ghonim, S Ernst, S Keegan, J Giannakidis, A Spadotto, V Voges, I Smith, G Boutsikou, M Montanaro, C Wong, T Ho, SY McCarthy, K Shore, D Dimopoulos, K Uebing, A Swan, L Li, W Pennell, D Gatzoulis, M Babu-Narayan, S |
Item Type: | Journal Article |
Abstract: | Background - Adults with repaired tetralogy of Fallot (rTOF) die prematurely from ventricular tachycardia (VT) and sudden cardiac death. Inducible VT predicts mortality. Ventricular scar, the key substrate for VT, can be non-invasively defined with late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) but whether this relates to inducible VT is unknown. Methods - Sixty-nine consecutive rTOF patients (43 male, mean 40{plus minus}15 years) clinically scheduled for invasive programmed VT-stimulation were prospectively recruited for prior 3D LGE CMR. Ventricular LGE was segmented and merged with reconstructed cardiac chambers and LGE volume measured. Results - VT was induced in 22(31%) patients. Univariable predictors of inducible VT included increased RV LGE (OR 1.15;p=0.001 per cm3), increased non-apical vent LV LGE (OR 1.09;p=0.008 per cm3), older age (OR 1.6;p=0.01 per decile), QRS duration ≥180ms (OR 3.5;p=0.02), history of non-sustained VT (OR 3.5; p=0.02) and previous clinical sustained VT (OR 12.8;p=0.003); only prior sustained VT (OR 8.02;p=0.02) remained independent in bivariable analyses after controlling for RV LGE volume (OR 1.14;p=0.003). An RV LGE volume of 25cm3 had 72% sensitivity and 81% specificity for predicting inducible VT (AUC 0.81;p<0.001). At the extreme cutoffs for 'ruling-out' and 'ruling-in' inducible VT, RV LGE >10cm3 was 100% sensitive and >36cm3 was 100% specific for predicting inducible VT. Conclusions - 3D LGE CMR-defined scar burden is independently associated with inducible VT and may help refine patient selection for programmed VT-stimulation when applied to an at least intermediate clinical risk cohort. |
Issue Date: | Nov-2020 |
Date of Acceptance: | 14-Sep-2020 |
URI: | http://hdl.handle.net/10044/1/83626 |
DOI: | 10.1161/CIRCEP.119.008321 |
ISSN: | 1941-3084 |
Publisher: | Lippincott, Williams & Wilkins |
Start Page: | 1331 |
End Page: | 1341 |
Journal / Book Title: | Circulation: Arrhythmia and Electrophysiology |
Volume: | 13 |
Issue: | 11 |
Copyright Statement: | © 2020 American Heart Association, Inc. |
Sponsor/Funder: | British Heart Foundation British Heart Foundation |
Funder's Grant Number: | FS/11/38/28864 EX/18/1/34296 |
Keywords: | Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology gadolinium magnetic resonance imaging myocardium tetralogy of Fallot ventricular tachycardia CONGENITAL HEART-DISEASE MYOCARDIAL FIBROSIS DEATH SCAR STIMULATION ARRHYTHMIAS MANAGEMENT ABLATION OUTCOMES MARKERS gadolinium magnetic resonance imaging myocardium tetralogy of Fallot ventricular tachycardia Cardiovascular System & Hematology 1102 Cardiorespiratory Medicine and Haematology 1103 Clinical Sciences 1116 Medical Physiology |
Publication Status: | Published |
Online Publication Date: | 2020-10-06 |
Appears in Collections: | National Heart and Lung Institute Faculty of Medicine |