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A head mounted device stimulator for optogenetic retinal prosthesis
File | Description | Size | Format | |
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A head mounted device stimulator for optogenetic retinal prosthesis.pdf | Accepted version | 4.39 MB | Adobe PDF | View/Open |
Title: | A head mounted device stimulator for optogenetic retinal prosthesis |
Authors: | Soltan, A Barrett, JM Maaskant, P Armstrong, N Al-Atabany, W Chaudet, L Neil, M Sernagor, E Degenaar, P |
Item Type: | Journal Article |
Abstract: | Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinitis pigmentosa where there is a remaining viable communication link between the retina and the visual cortex. Approach. We design and implement the headset using a high-density µLED matrix, Raspberry Pi, microcontroller from NXP and virtual reality lens. Then, a test platform is developed to evaluate the performance of the headset and the optical system. Furthermore, image simplification algorithms are used to simplify the scene to be sent to the retina. Moreover, in vivo evaluation of the genetically modified retina response at different light intensity is discussed to prove the reliability of the proposed system. Main results. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90 kcd m−2. We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW mm−2 irradiance on the retina within the regulatory guidance, but which is capable of an average peak irradiance of 1.35 mW mm−2. As this is lower than the commonly accepted threshold for channelrhodopsin-2, we demonstrate efficacy through an optical model of an eye onto a biological retina. Significance. We demonstrate a fully functional 8100-pixel headset system including software/hardware which can operate on a standard consumer battery for periods exceeding a 24 h recharge cycle. The headset is capable of delivering enough light to stimulate the genetically modified retina cells and also keeping the amount of light below the regulation threshold for safety. |
Issue Date: | 9-Oct-2018 |
Date of Acceptance: | 29-Aug-2018 |
URI: | http://hdl.handle.net/10044/1/83119 |
DOI: | 10.1088/1741-2552/aadd55 |
ISSN: | 1741-2552 |
Publisher: | IOP Publishing |
Journal / Book Title: | Journal of Neural Engineering |
Volume: | 15 |
Issue: | 6 |
Copyright Statement: | © 2018 IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
Sponsor/Funder: | Engineering & Physical Science Research Council (E Commission of the European Communities Engineering & Physical Science Research Council (E |
Funder's Grant Number: | GR/S85764/01 249867 EP/K503733/1 |
Keywords: | Science & Technology Technology Life Sciences & Biomedicine Engineering, Biomedical Neurosciences Engineering Neurosciences & Neurology retinal prosthesis visual prosthesis optogenetics electronics regulatory channelrhodopsin retinitis pigmentosa RESTORES VISUAL RESPONSES VISION RECOGNITION PERFORMANCE IMPAIRMENT CIRCUITS FIELD MICE Algorithms Channelrhodopsins Humans Optogenetics Photic Stimulation Prosthesis Design Retina Retinitis Pigmentosa Software Virtual Reality Visual Cortex Visual Prosthesis Visual Cortex Retina Humans Retinitis Pigmentosa Prosthesis Design Photic Stimulation Algorithms Software Visual Prosthesis Optogenetics Channelrhodopsins Virtual Reality Science & Technology Technology Life Sciences & Biomedicine Engineering, Biomedical Neurosciences Engineering Neurosciences & Neurology retinal prosthesis visual prosthesis optogenetics electronics regulatory channelrhodopsin retinitis pigmentosa PIXELIZED VISION SYSTEM RESTORES VISUAL RESPONSES LIGHT-EMITTING-DIODES RETINITIS-PIGMENTOSA NEURAL STIMULATION CHANNELRHODOPSIN-2 RECOGNITION PERFORMANCE IMPAIRMENT BLINDNESS Biomedical Engineering 0903 Biomedical Engineering 1103 Clinical Sciences 1109 Neurosciences |
Publication Status: | Published |
Article Number: | ARTN 065002 |
Online Publication Date: | 2018-10-09 |
Appears in Collections: | Physics Photonics |
This item is licensed under a Creative Commons License