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A head mounted device stimulator for optogenetic retinal prosthesis

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Title: A head mounted device stimulator for optogenetic retinal prosthesis
Authors: Soltan, A
Barrett, JM
Maaskant, P
Armstrong, N
Al-Atabany, W
Chaudet, L
Neil, M
Sernagor, E
Degenaar, P
Item Type: Journal Article
Abstract: Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinitis pigmentosa where there is a remaining viable communication link between the retina and the visual cortex. Approach. We design and implement the headset using a high-density µLED matrix, Raspberry Pi, microcontroller from NXP and virtual reality lens. Then, a test platform is developed to evaluate the performance of the headset and the optical system. Furthermore, image simplification algorithms are used to simplify the scene to be sent to the retina. Moreover, in vivo evaluation of the genetically modified retina response at different light intensity is discussed to prove the reliability of the proposed system. Main results. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90 kcd m−2. We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW mm−2 irradiance on the retina within the regulatory guidance, but which is capable of an average peak irradiance of 1.35 mW mm−2. As this is lower than the commonly accepted threshold for channelrhodopsin-2, we demonstrate efficacy through an optical model of an eye onto a biological retina. Significance. We demonstrate a fully functional 8100-pixel headset system including software/hardware which can operate on a standard consumer battery for periods exceeding a 24 h recharge cycle. The headset is capable of delivering enough light to stimulate the genetically modified retina cells and also keeping the amount of light below the regulation threshold for safety.
Issue Date: 9-Oct-2018
Date of Acceptance: 29-Aug-2018
URI: http://hdl.handle.net/10044/1/83119
DOI: 10.1088/1741-2552/aadd55
ISSN: 1741-2552
Publisher: IOP Publishing
Journal / Book Title: Journal of Neural Engineering
Volume: 15
Issue: 6
Copyright Statement: © 2018 IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Sponsor/Funder: Engineering & Physical Science Research Council (E
Commission of the European Communities
Engineering & Physical Science Research Council (E
Funder's Grant Number: GR/S85764/01
249867
EP/K503733/1
Keywords: Science & Technology
Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Neurosciences
Engineering
Neurosciences & Neurology
retinal prosthesis
visual prosthesis
optogenetics
electronics
regulatory
channelrhodopsin
retinitis pigmentosa
RESTORES VISUAL RESPONSES
VISION
RECOGNITION
PERFORMANCE
IMPAIRMENT
CIRCUITS
FIELD
MICE
Algorithms
Channelrhodopsins
Humans
Optogenetics
Photic Stimulation
Prosthesis Design
Retina
Retinitis Pigmentosa
Software
Virtual Reality
Visual Cortex
Visual Prosthesis
Visual Cortex
Retina
Humans
Retinitis Pigmentosa
Prosthesis Design
Photic Stimulation
Algorithms
Software
Visual Prosthesis
Optogenetics
Channelrhodopsins
Virtual Reality
Science & Technology
Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Neurosciences
Engineering
Neurosciences & Neurology
retinal prosthesis
visual prosthesis
optogenetics
electronics
regulatory
channelrhodopsin
retinitis pigmentosa
PIXELIZED VISION SYSTEM
RESTORES VISUAL RESPONSES
LIGHT-EMITTING-DIODES
RETINITIS-PIGMENTOSA
NEURAL STIMULATION
CHANNELRHODOPSIN-2
RECOGNITION
PERFORMANCE
IMPAIRMENT
BLINDNESS
Biomedical Engineering
0903 Biomedical Engineering
1103 Clinical Sciences
1109 Neurosciences
Publication Status: Published
Article Number: ARTN 065002
Online Publication Date: 2018-10-09
Appears in Collections:Physics
Photonics



This item is licensed under a Creative Commons License Creative Commons