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Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium

Title: Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium
Authors: Wolters, FJ
Chibnik, LB
Waziry, R
Anderson, R
Berr, C
Beiser, A
Bis, JC
Blacker, D
Bos, D
Brayne, C
Dartigues, J-F
Darweesh, SKL
Davis-Plourde, KL
De Wolf, F
Debette, S
Dufouil, C
Fornage, M
Goudsmit, J
Grasset, L
Gudnason, V
Hadjichrysanthou, C
Helmer, C
Ikram, MA
Ikram, MK
Joas, E
Kern, S
Kuller, LH
Launer, L
Lopez, OL
Matthews, FE
McRae-McKee, K
Meirelles, O
Mosley, TH
Pase, MP
Psaty, BM
Satizabal, CL
Seshadri, S
Skoog, I
Stephan, BCM
Wetterberg, H
Wong, MM
Zettergren, A
Hofman, A
Item Type: Journal Article
Abstract: OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
Issue Date: 4-Aug-2020
Date of Acceptance: 31-Jan-2020
URI: http://hdl.handle.net/10044/1/82976
DOI: 10.1212/WNL.0000000000010022
ISSN: 0028-3878
Publisher: Lippincott, Williams & Wilkins
Start Page: e519
End Page: e531
Journal / Book Title: Neurology
Volume: 95
Issue: 5
Copyright Statement: © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloadingand sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Sponsor/Funder: Janssen Vaccines & Prevention B.V
Johnson & Johnson Pharmaceutical and Research Comp
Funder's Grant Number: P22539540R
Keywords: Neurology & Neurosurgery
1103 Clinical Sciences
1109 Neurosciences
1702 Cognitive Sciences
Publication Status: Published
Conference Place: United States
Online Publication Date: 2020-07-01
Appears in Collections:School of Public Health