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Transient and partial nuclear lamina disruption promotes chromosome movement in early meiotic prophase

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Title: Transient and partial nuclear lamina disruption promotes chromosome movement in early meiotic prophase
Authors: Link, J
Paouneskou, D
Velkova, M
Daryabeigi, A
Laos, T
Labella, S
Barroso, C
Pinol, SP
Montoya, A
Kramer, H
Woglar, A
Baudrimont, A
Markert, SM
Stigloher, C
Martinez-Perez, E
Dammermann, A
Alsheimer, M
Zetka, M
Jantsch, V
Item Type: Journal Article
Abstract: Meiotic chromosome movement is important for the pairwise alignment of homologous chromosomes, which is required for correct chromosome segregation. Movement is driven by cytoplasmic forces, transmitted to chromosome ends by nuclear membrane-spanning proteins. In animal cells, lamins form a prominent scaffold at the nuclear periphery, yet the role lamins play in meiotic chromosome movement is unclear. We show that chromosome movement correlates with reduced lamin association with the nuclear rim, which requires lamin phosphorylation at sites analogous to those that open lamina network crosslinks in mitosis. Failure to remodel the lamina results in delayed meiotic entry, altered chromatin organization, unpaired or interlocked chromosomes, and slowed chromosome movement. The remodeling kinases are delivered to lamins via chromosome ends coupled to the nuclear envelope, potentially enabling crosstalk between the lamina and chromosomal events. Thus, opening the lamina network plays a role in modulating contacts between chromosomes and the nuclear periphery during meiosis.
Issue Date: 23-Apr-2018
Date of Acceptance: 23-Mar-2018
URI: http://hdl.handle.net/10044/1/82922
DOI: 10.1016/j.devcel.2018.03.018
ISSN: 1534-5807
Publisher: Elsevier
Start Page: 212
End Page: 225
Journal / Book Title: Developmental Cell
Volume: 45
Issue: 2
Copyright Statement: © 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Developmental Biology
C. ELEGANS MEIOSIS
CAENORHABDITIS-ELEGANS
PORE COMPLEXES
CDC2 KINASE
ENVELOPE
MITOSIS
SYNAPSIS
PHOSPHORYLATION
PROGRESSION
CELLS
C. elegans
chromosome movement
chromosome pairing
lamin
meiosis
nuclear envelope
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Nucleus
Chromosome Pairing
Chromosome Segregation
Chromosomes
Cytoplasm
Gene Expression Regulation
Meiotic Prophase I
Nuclear Envelope
Nuclear Lamina
Phosphorylation
Nuclear Envelope
Nuclear Lamina
Chromosomes
Cell Nucleus
Cytoplasm
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Chromosome Segregation
Meiotic Prophase I
Chromosome Pairing
Gene Expression Regulation
Phosphorylation
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Developmental Biology
C. ELEGANS MEIOSIS
CAENORHABDITIS-ELEGANS
PORE COMPLEXES
CDC2 KINASE
ENVELOPE
MITOSIS
SYNAPSIS
PHOSPHORYLATION
PROGRESSION
CELLS
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2018-04-23
Appears in Collections:Institute of Clinical Sciences



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