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Permanent bilateral carotid filters for stroke prevention in atrial fibrillation.

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Title: Permanent bilateral carotid filters for stroke prevention in atrial fibrillation.
Authors: De Potter, T
Yodfat, O
Shinar, G
Neta, A
Reddy, VY
Neuzil, P
Veltkamp, R
Connolly, SJ
Item Type: Journal Article
Abstract: PURPOSE OF REVIEW: A novel permanent carotid filter device for percutaneous implantation was developed for the purpose of stroke prevention. In this review, we cover rationale, existing preclinical and clinical data, and potential future directions for research using such a device. RECENT FINDINGS: The Vine™ filter was assessed for safety in sheep and in 2 observational human studies, the completed CAPTURE 1 (n = 25) and the ongoing CAPTURE 2 (planned n = 100). CAPTURE 1 has shown high procedural and long-term implant safety. A control group was not available for comparison. A mechanical filter for permanent stroke prevention can be implanted bilaterally in the common carotid artery safely and efficiently. A randomized trial is planned for 2021 (n = 3500, INTERCEPT) to demonstrate superiority of a filter + anticoagulation strategy over anticoagulation alone in patients at high risk for ischemic stroke.
Issue Date: 10-Sep-2020
Date of Acceptance: 1-Sep-2020
URI: http://hdl.handle.net/10044/1/82818
DOI: 10.1007/s11886-020-01388-w
ISSN: 1523-3782
Publisher: Springer
Start Page: 144
End Page: 144
Journal / Book Title: Current Cardiology Reports
Volume: 22
Issue: 11
Copyright Statement: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: St Marys Development Trust
Commission of the European Communities
Funder's Grant Number: RE:SOBELL CHAIR
754517
Keywords: Atrial fibrillation
Carotid filter
Common carotid artery
Embolic protection
Stroke prevention
Atrial fibrillation
Carotid filter
Common carotid artery
Embolic protection
Stroke prevention
1102 Cardiorespiratory Medicine and Haematology
Cardiovascular System & Hematology
Publication Status: Published online
Conference Place: United States
Online Publication Date: 2020-09-10
Appears in Collections:Faculty of Medicine
Department of Brain Sciences



This item is licensed under a Creative Commons License Creative Commons