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Size dependency of gold nanoparticles interacting with model membranes

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Title: Size dependency of gold nanoparticles interacting with model membranes
Authors: Contini, C
Hindley, J
Macdonald, T
Barritt, J
Ces, O
Quirke, N
Item Type: Journal Article
Abstract: The rapid development of nanotechnology has led to an increase in the number and variety of engineered nanomaterials in the environment. Gold nanoparticles (AuNPs) are an example of a commonly studied nanomaterial whose highly tailorable properties have generated significant interest through a wide range of research fields. In the present work, we characterise the AuNP-lipid membrane interaction by coupling qualitative data with quantitative measurements of the enthalpy change of interaction. We investigate the interactions between citrate-stabilised AuNPs ranging from 5 to 60 nm in diameter and large unilamellar vesicles acting as a model membrane system. Our results reveal the existence of two critical AuNP diameters which determine their fate when in contact with a lipid membrane. The results provide new insights into the size dependent interaction between AuNPs and lipid bilayers which is of direct relevance to nanotoxicology and to the design of NP vectors.
Issue Date: 17-Sep-2020
Date of Acceptance: 17-Aug-2020
URI: http://hdl.handle.net/10044/1/82385
DOI: 10.1038/s42004-020-00377-y
ISSN: 2399-3669
Publisher: Nature Research
Start Page: 1
End Page: 12
Journal / Book Title: Communications Chemistry
Volume: 3
Copyright Statement: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Sponsor/Funder: Commission of the European Communities
Commission of the European Communities
Engineering & Physical Science Research Council (E
Funder's Grant Number: 686098
686098
CHBBC_P81995
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
NILE RED
ADSORPTION
LIPOSOMES
DYNAMICS
VESICLES
RELEASE
PHASE
Publication Status: Published
Article Number: 130
Online Publication Date: 2020-09-17
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Chemical Engineering
Faculty of Natural Sciences
Faculty of Engineering



This item is licensed under a Creative Commons License Creative Commons