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The impact of hypoxia on neutrophil degranulation and consequences for the host
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Title: | The impact of hypoxia on neutrophil degranulation and consequences for the host |
Authors: | Lodge, KM Cowburn, AS Li, W Condliffe, AM |
Item Type: | Journal Article |
Abstract: | Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the release of neutrophil extracellular traps; all of these microbicidal strategies require the deployment of cytotoxic proteins and proteases, packaged during neutrophil development within cytoplasmic granules. Neutrophils operate in infected and inflamed tissues, which can be profoundly hypoxic. Neutrophilic infiltration of hypoxic tissues characterises a myriad of acute and chronic infectious and inflammatory diseases, and as well as potentially protecting the host from pathogens, neutrophil granule products have been implicated in causing collateral tissue damage in these scenarios. This review discusses the evidence for the enhanced secretion of destructive neutrophil granule contents observed in hypoxic environments and the potential mechanisms for this heightened granule exocytosis, highlighting implications for the host. Understanding the dichotomy of the beneficial and detrimental consequences of neutrophil degranulation in hypoxic environments is crucial to inform potential neutrophil-directed therapeutics in order to limit persistent, excessive, or inappropriate inflammation. |
Issue Date: | 11-Feb-2020 |
Date of Acceptance: | 8-Feb-2020 |
URI: | http://hdl.handle.net/10044/1/82379 |
DOI: | 10.3390/ijms21041183 |
ISSN: | 1422-0067 |
Publisher: | MDPI AG |
Start Page: | 1 |
End Page: | 21 |
Journal / Book Title: | International Journal of Molecular Sciences |
Volume: | 21 |
Issue: | 4 |
Copyright Statement: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry neutrophils hypoxia degranulation ENDOTHELIAL-GROWTH-FACTOR WEIBEL-PALADE BODIES PHOSPHOINOSITIDE 3-KINASE INDUCIBLE FACTOR-1-ALPHA STREPTOCOCCUS-PNEUMONIAE PULMONARY-HYPERTENSION BACTERICIDAL CAPACITY INFLAMMATORY CELLS SECRETORY VESICLES MAMMALIAN TARGET degranulation hypoxia neutrophils Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry neutrophils hypoxia degranulation ENDOTHELIAL-GROWTH-FACTOR WEIBEL-PALADE BODIES PHOSPHOINOSITIDE 3-KINASE INDUCIBLE FACTOR-1-ALPHA STREPTOCOCCUS-PNEUMONIAE PULMONARY-HYPERTENSION BACTERICIDAL CAPACITY INFLAMMATORY CELLS SECRETORY VESICLES MAMMALIAN TARGET Chemical Physics 0399 Other Chemical Sciences 0604 Genetics 0699 Other Biological Sciences |
Publication Status: | Published |
Article Number: | ARTN 1183 |
Online Publication Date: | 2020-02-11 |
Appears in Collections: | National Heart and Lung Institute |
This item is licensed under a Creative Commons License