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Characterisation of the expression of neurotensin and its receptors in human colorectal cancer and its clinical implications

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Title: Characterisation of the expression of neurotensin and its receptors in human colorectal cancer and its clinical implications
Authors: Qiu, S
Nikolaou, S
Zhu, J
Jeffery, P
Goldin, R
Kinross, J
Alexander, J
Rasheed, S
Tekkis, P
Kontovounisios, C
Item Type: Journal Article
Abstract: Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association of CRC expression of neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 and NTSR3) and clinical outcomes. Methods: A prospective cohort study which quantifies the protein expression of NTS, NTSR1 and NTSR3 in human CRCs using immunohistochemistry. Expression levels were then compared with clinico-pathological outcome including histological grade, overall survival (OS) and disease-free survival (DFS). Results: Sixty-four patients were enrolled with median follow-up of 44.0 months. There was significantly higher expression of NTS in cancer tissue in CRC with higher T stages (p < 0.01), N stages (p = 0.03), and AJCC clinical stages (p = 0.04). There was significantly higher expression of NTS, NTSR1 and NTSR3 in cancer tissue compared to surrounding normal epithelium (median H-score 163.5 vs 97.3, p < 0.01). There was significantly shorter DFS in individuals with CRC with high levels of NTS compared to lower levels of NTS (35.8 months 95% CI 28.7–42.8 months vs 46.4 months 95% CI 42.2–50.5 months, respectively, p = 0.02). Above median NTS expression in cancer tissue was a significant risk factor for disease recurrence (HR 4.10, 95% CI 1.14–14.7, p = 0.03). Discussion: The expression of NTS and its receptors has the potential to be utilised as a predictive and prognostic marker in colorectal cancer for postoperative selection for adjuvant therapy and identify individuals for novel therapies targeting the neurotensinergic pathways. Conclusions: High NTS expression appears to be associated with more advanced CRC and worse DFS.
Issue Date: 5-Aug-2020
Date of Acceptance: 2-Aug-2020
URI: http://hdl.handle.net/10044/1/82176
DOI: 10.3390/biom10081145
ISSN: 2218-273X
Publisher: MDPI AG
Start Page: 1
End Page: 15
Journal / Book Title: Biomolecules
Volume: 10
Issue: 8
Copyright Statement: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: biomarker
colorectal cancer
neurotensin
0601 Biochemistry and Cell Biology
Publication Status: Published
Online Publication Date: 2020-08-05
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Department of Surgery and Cancer
National Heart and Lung Institute
Faculty of Medicine



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