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Anticancer polymers via the biginelli reaction

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Li et al, ACS Macro Letters 2020_Accepted Manuscript.pdfAccepted version1.12 MBAdobe PDFView/Open
Li et al, ACS Macro Letters 2020_Supporting Information.pdfSupporting information4.77 MBAdobe PDFView/Open
Title: Anticancer polymers via the biginelli reaction
Authors: Li, Y
Tan, T
Zhao, Y
Wei, Y
Wang, D
Chen, R
Tao, L
Item Type: Journal Article
Abstract: We developed a polymer–drug strategy to explore anticancer polymers. A series of monomers containing groups with potential anticancer activity have been facilely prepared through the Biginelli reaction. These monomers were used to produce water-soluble polymers through convenient radical copolymerization. The resulting polymers are biocompatible and can be directly used to suppress proliferation of different cancer cells without the release of small molecules. Theoretical calculations revealed that Biginelli groups in polymers had strong interaction with the Eg5 protein, which is highly expressed in cancer cells and is closely related to cell mitosis. Subsequent cell experiments confirmed that a screened polymer is efficient in inhibiting mitosis in different cancer cells. Our study of exploring functional polymers via the combination of multicomponent reactions and theoretical calculation resulted in promising anticancer polymers, which might pave a path for de novo designing of functional polymers and have important implications in the fields of organic, computational, and polymer chemistry.
Issue Date: 18-Aug-2020
Date of Acceptance: 17-Aug-2020
URI: http://hdl.handle.net/10044/1/81945
DOI: 10.1021/acsmacrolett.0c00496
ISSN: 2161-1653
Publisher: American Chemical Society (ACS)
Start Page: 1249
End Page: 1254
Journal / Book Title: ACS Macro Letters
Volume: 9
Copyright Statement: © 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmacrolett.0c00496
Keywords: 0303 Macromolecular and Materials Chemistry
0306 Physical Chemistry (incl. Structural)
Publication Status: Published
Online Publication Date: 2020-08-18
Appears in Collections:Chemical Engineering