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Zero electrical power pump for portable high-performance liquid chromatography

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Title: Zero electrical power pump for portable high-performance liquid chromatography
Authors: Chatzimichail, S
Casey, D
Salehi-Reyhani, A
Item Type: Journal Article
Abstract: A major trend in analytical chemistry is the miniaturization of laboratory instrumentation. We report a pump requiring no power to operate based on the controlled expansion of a pre-pressurised gas for use in portable applications of high-performance liquid chromatography. The performance of the gas pump is characterised and integrated into a compact liquid chromatography system capable of isocratic separations integrating an LED-based UV-absorption detector. The system weighed 6.7 kg when the mobile phase reservoir was fully charged with 150 mL solvent and included an on-board computer to control the system and analyse data. We characterise the flow-rate through chromatography columns with a variety of geometries and packing materials for a range of pressures up to 150 bar. The maximum variation in flow rate was measured to be 6.5 nL min−1, limited by the resolution of the flow detector. All tests were made on battery power and results are a mixture of those made in the laboratory and in the field. Additionally, we performed a series of 1 m drop tests on the device and show the system's high tolerance to mechanical shocks during operation in the field.
Issue Date: 7-Nov-2019
Date of Acceptance: 24-Aug-2019
URI: http://hdl.handle.net/10044/1/81563
DOI: 10.1039/c9an01302d
ISSN: 0003-2654
Publisher: Royal Society of Chemistry
Start Page: 6207
End Page: 6213
Journal / Book Title: The Analyst
Volume: 144
Issue: 21
Copyright Statement: © The Royal Society of Chemistry 2019. This article is Open Access under CC-BY Licence (https://creativecommons.org/licenses/by/3.0/)
Keywords: Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
ELECTROOSMOTIC PUMP
AMINO-ACIDS
DETECTOR
Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
ELECTROOSMOTIC PUMP
AMINO-ACIDS
DETECTOR
Analytical Chemistry
0301 Analytical Chemistry
0399 Other Chemical Sciences
Publication Status: Published
Open Access location: https://pubs.rsc.org/en/content/articlelanding/2019/an/c9an01302d
Online Publication Date: 2019-10-01
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons