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Update on house dust mite allergen avoidance measures for asthma

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Title: Update on house dust mite allergen avoidance measures for asthma
Authors: Zuiani, C
Custovic, A
Item Type: Journal Article
Abstract: Purpose of Review To critically review the evidence in favor or against the use of house dust mite (HDM) allergen avoidance measures in patients with asthma. Recent Findings Systematic reviews and meta-analyses suggested no positive effect of mite allergen avoidance strategies on asthma outcomes, resulting in a lack of consensus regarding the utility of these measures. However, such analyses have a number limitations and might not be the most adequate tool to evaluate current evidence and to derive clinical recommendations regarding mite allergen avoidance in asthmatic patients. We should not disproportionately rely on the results of meta-analyses and systematic reviews to inform clinical practice and asthma guidelines in this area. Recent high-quality evidence from randomized controlled trial in children confirmed that mite allergen–impermeable bed encasings reduce emergency hospital attendance with acute severe asthma exacerbations. Summary Until better evidence is available, we suggest that physicians should adopt a pragmatic approach to mite allergen avoidance and advise sensitized patients to implement a multifaceted set of measures to achieve as great a reduction in exposure as possible. Potential predictors of positive response (e.g., patient’s sensitization and exposure status) can pragmatically be evaluated using the size of skin test wheal or the titer of allergen-specific IgE. Finally, the intervention should be started as early as possible.
Issue Date: 19-Jun-2020
Date of Acceptance: 1-Jun-2020
URI: http://hdl.handle.net/10044/1/81156
DOI: 10.1007/s11882-020-00948-y
ISSN: 1529-7322
Publisher: Springer
Start Page: 1
End Page: 8
Journal / Book Title: Current Allergy and Asthma Reports
Volume: 20
Issue: 9
Copyright Statement: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
House dust mite
Asthma
Avoidance
Exposure
Allergen
Mite
RISK-FACTOR
BRONCHIAL HYPERRESPONSIVENESS
ENVIRONMENTAL INTERVENTIONS
LUNG-FUNCTION
EARLY-LIFE
EXPOSURE
CHILDREN
SENSITIZATION
CHILDHOOD
REDUCTION
Allergen
Asthma
Avoidance
Exposure
House dust mite
Mite
Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
House dust mite
Asthma
Avoidance
Exposure
Allergen
Mite
RISK-FACTOR
BRONCHIAL HYPERRESPONSIVENESS
ENVIRONMENTAL INTERVENTIONS
LUNG-FUNCTION
EARLY-LIFE
EXPOSURE
CHILDREN
SENSITIZATION
CHILDHOOD
REDUCTION
Allergy
Publication Status: Published
Article Number: ARTN 50
Online Publication Date: 2020-06-19
Appears in Collections:National Heart and Lung Institute



This item is licensed under a Creative Commons License Creative Commons