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The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields

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Title: The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields
Authors: Pedrosa, V
Clopath, C
Item Type: Journal Article
Abstract: During the exploration of novel environments, place fields are rapidly formed in hippocampal CA1 neurons. Place cell firing rate increases in early stages of exploration of novel environments but returns to baseline levels in familiar environments. Although similar in amplitude and width, place fields in familiar environments are more stable than in novel environments. We propose a computational model of the hippocampal CA1 network, which describes the formation, dynamics and stabilization of place fields. We show that although somatic disinhibition is sufficient to form place fields, dendritic inhibition along with synaptic plasticity is necessary for place field stabilization. Our model suggests that place cell stability can be attributed to strong excitatory synaptic weights and strong dendritic inhibition. We show that the interplay between somatic and dendritic inhibition balances the increased excitatory weights, such that place cells return to their baseline firing rate after exploration. Our model suggests that different types of interneurons are essential to unravel the mechanisms underlying place field plasticity. Finally, we predict that artificially induced dendritic events can shift place fields even after place field stabilization.
Issue Date: 10-Jul-2020
Date of Acceptance: 15-May-2020
URI: http://hdl.handle.net/10044/1/81018
DOI: 10.1371/journal.pcbi.1007955
ISSN: 1553-734X
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS Computational Biology
Volume: 16
Issue: 7
Copyright Statement: © 2020 Pedrosa, Clopath. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Simons Foundation
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Award ID:564408
Keywords: Bioinformatics
01 Mathematical Sciences
06 Biological Sciences
08 Information and Computing Sciences
Publication Status: Published
Article Number: e1007955
Online Publication Date: 2020-07-10
Appears in Collections:Faculty of Engineering
Bioengineering



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