IRUS Total

Disease prevention not decolonization – a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms

File Description SizeFormat 
ciaa948.pdfPublished version364.19 kBAdobe PDFView/Open
CID_Supplmentary_Brief Report_05062020.docxSupporting information172.89 kBMicrosoft WordView/Open
Title: Disease prevention not decolonization – a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms
Authors: Ghani, R
Mullish, BH
McDonald, JAK
Ghazy, A
Williams, HRT
Brannigan, ET
Mookerjee, S
Satta, G
Gilchrist, M
Duncan, N
Corbett, R
Innes, AJ
Pavlu, J
Thursz, MR
Davies, F
Marchesi, JR
Item Type: Journal Article
Abstract: Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia and length of stay in 20 patients colonized/ infected with MDRO receiving FMT (compared to pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.
Issue Date: 15-Apr-2021
Date of Acceptance: 8-Jun-2020
URI: http://hdl.handle.net/10044/1/80890
DOI: 10.1093/cid/ciaa948
ISSN: 1058-4838
Publisher: Oxford University Press (OUP)
Start Page: 1444
End Page: 1447
Journal / Book Title: Clinical Infectious Diseases
Volume: 72
Issue: 8
Copyright Statement: © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Supplementary data
Sponsor/Funder: Medical Research Council
Medical Research Council (MRC)
Imperial College Healthcare NHS Trust- BRC Funding
Wellcome Trust Institutional Strategic Support Fund (co-funded by Wellcome Trust and Imperial College London)
Imperial College Healthcare NHS Trust: Research Capability Funding (RCF)
Funder's Grant Number: MR/R00875/1
Keywords: allogeneic hematopoietic cell transplantation
antimicrobial resistance
fecal microbiota transplant
gut microbiome
multi-drug resistant bacteria
06 Biological Sciences
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2020-07-18
Appears in Collections:Department of Immunology and Inflammation
Department of Metabolism, Digestion and Reproduction
Department of Infectious Diseases
Faculty of Medicine
Faculty of Natural Sciences