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Amyloid PET imaging in clinical practice

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Title: Amyloid PET imaging in clinical practice
Authors: Kolanko, M
Loreto, F
Win, Z
Patel, N
Perry, R
Carswell, C
Gontsarova, A
Malhotra, P
Item Type: Journal Article
Abstract: The introduction of Amyloid PET imaging enables in vivo detection of brain beta-amyloid deposition, one of the neuropathological hallmarks of Alzheimer disease. There is increasing evidence in support of the clinical utility of Amyloid PET with major studies demonstrating that Amyloid PET improves diagnostic accuracy, increases diagnostic certainty, and results in therapeutic changes. Appropriate use criteria have been developed by the Amyloid Imaging Taskforce (AIT), to guide clinicians by predefining certain scenarios in which amyloid PET would be justified. In this review we aim to provide a practical guide on how and when to use Amyloid PET based on the available research and our own experience. We discuss three main appropriate indications for Amyloid PET and illustrate with them with clinical cases. We stress the importance of a multidisciplinary approach when deciding which patients would benefit from Amyloid PET imaging. Finally, we highlight some practical points and common pitfalls in interpretation.
Issue Date: 23-Nov-2020
Date of Acceptance: 26-May-2020
URI: http://hdl.handle.net/10044/1/80724
DOI: 10.1136/practneurol-2019-002468
ISSN: 1474-7766
Publisher: BMJ Publishing Group
Start Page: 451
End Page: 462
Journal / Book Title: Practical Neurology
Volume: 20
Issue: 6
Copyright Statement: © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. This article has been accepted for publication in Practical Neurology following peer review. The definitive copyedited, typeset version Kolanko MA, Win Z, Loreto F, et alAmyloid PET imaging in clinical practice. Practical Neurology 2020;20:451-462 is available online at: http://dx.doi.org/10.1136/practneurol-2019-002468
Sponsor/Funder: Alzheimer's Society
Funder's Grant Number: 452 (AS-PG-18-032)
Neurology & Neurosurgery
Publication Status: Published
Online Publication Date: 2020-09-24
Appears in Collections:Faculty of Medicine
Department of Brain Sciences