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Novel approach to imaging active takayasu arteritis using somatostatin receptor positron emission tomography/magnetic resonance imaging.

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Title: Novel approach to imaging active takayasu arteritis using somatostatin receptor positron emission tomography/magnetic resonance imaging.
Authors: Tarkin, JM
Wall, C
Gopalan, D
Aloj, L
Manavaki, R
Fryer, TD
Aboagye, EO
Bennett, MR
Peters, JE
Rudd, JHF
Mason, JC
Item Type: Journal Article
Abstract: Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is an important diagnostic test for Takayasu arteritis (TAK),118F-FDG lacks inflammatory cell selectivity and cannot accurately distinguish arteritis from metabolically active vascular remodeling.2 This observation has led to the search for more sensitive and specific PET tracers for TAK. Macrophage activation antigen SST2 (somatostatin receptor subtype-2) PET represents a potential alternative imaging biomarker for defining disease activity in TAK, as macrophages are a major feature of the inflammatory infiltrate. We aimed to determine the ability of SST2 PET/magnetic resonance imaging (MRI) to detect arteritis in 2 patients with clinically active TAK.
Issue Date: Jun-2020
Date of Acceptance: 1-May-2020
URI: http://hdl.handle.net/10044/1/80444
DOI: 10.1161/CIRCIMAGING.119.010389
ISSN: 1941-9651
Publisher: American Heart Association
Start Page: 1
End Page: 3
Journal / Book Title: Circulation: Cardiovascular Imaging
Volume: 13
Issue: 6
Copyright Statement: © 2020 American Heart Association, Inc.
Sponsor/Funder: United Kingdom Research and Innovation
Medical Research Council (MRC)
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council
Funder's Grant Number: MR/S004068/1
MR/S004068/2
RDC04
Keywords: Takayasu arteritis
aortic diseases
molecular imaging
positron emission tomography
vasculitis
Takayasu arteritis
aortic diseases
molecular imaging
positron emission tomography
vasculitis
1103 Clinical Sciences
Cardiovascular System & Hematology
Publication Status: Published
Conference Place: United States
Online Publication Date: 2020-05-28
Appears in Collections:Department of Immunology and Inflammation
Department of Surgery and Cancer
National Heart and Lung Institute