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A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species

Title: A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
Authors: Bacigalupe, R
Angeles Tormo-Mas, M
Penades, JR
Fitzgerald, JR
Item Type: Journal Article
Abstract: While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat to human and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of the multihost pathogen Staphylococcus aureus to adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.
Issue Date: 1-Nov-2019
Date of Acceptance: 1-Oct-2019
URI: http://hdl.handle.net/10044/1/80426
DOI: 10.1126/sciadv.aax0063
ISSN: 2375-2548
Publisher: American Association for the Advancement of Science
Journal / Book Title: Science Advances
Volume: 5
Issue: 11
Copyright Statement: © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
STAPHYLOCOCCUS-AUREUS REVEALS
GENOME
EVOLUTION
DYNAMICS
INSIGHTS
PROBABILITY
MUTATIONS
ORIGIN
SPREAD
Adaptation, Physiological
Animals
Genetic Drift
Host Specificity
Models, Genetic
Mutation
Sheep
Staphylococcal Infections
Staphylococcus aureus
Animals
Sheep
Staphylococcus aureus
Staphylococcal Infections
Adaptation, Physiological
Genetic Drift
Mutation
Models, Genetic
Host Specificity
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
STAPHYLOCOCCUS-AUREUS REVEALS
GENOME
EVOLUTION
DYNAMICS
INSIGHTS
PROBABILITY
MUTATIONS
ORIGIN
SPREAD
Publication Status: Published
Article Number: ARTN eaax0063
Appears in Collections:Department of Infectious Diseases