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A single natural nucleotide mutation alters bacterial pathogen host tropism

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Title: A single natural nucleotide mutation alters bacterial pathogen host tropism
Authors: Viana, D
Comos, M
McAdam, PR
Ward, MJ
Selva, L
Guinane, CM
Gonzalez-Munoz, BM
Tristan, A
Foster, SJ
Fitzgerald, JR
Penades, JR
Item Type: Journal Article
Abstract: The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary trajectory of the common rabbit clone of Staphylococcus aureus. We report that it evolved through a likely human-to-rabbit host jump over 40 years ago and that only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits. Related mutations were identified at the same locus in other rabbit strains of distinct clonal origin, consistent with convergent evolution. This first report of a single mutation that was sufficient to alter the host tropism of a microorganism during its evolution highlights the capacity of some pathogens to readily expand into new host species populations.
Issue Date: 1-Apr-2015
Date of Acceptance: 16-Jan-2015
URI: http://hdl.handle.net/10044/1/80392
DOI: 10.1038/ng.3219
ISSN: 1061-4036
Publisher: Nature Research
Start Page: 361
End Page: 366
Journal / Book Title: Nature Genetics
Volume: 47
Issue: 4
Copyright Statement: © 2015 Springer Nature Limited
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
STAPHYLOCOCCUS-AUREUS REVEALS
LISTERIA-MONOCYTOGENES
AMINO-ACID
ADAPTATION
PROTEIN
VIRUS
GENOMICS
ORIGIN
RANGE
TRANSMISSION
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
STAPHYLOCOCCUS-AUREUS REVEALS
LISTERIA-MONOCYTOGENES
AMINO-ACID
ADAPTATION
PROTEIN
VIRUS
GENOMICS
ORIGIN
RANGE
TRANSMISSION
Animals
Evolution, Molecular
Genetic Speciation
Host Specificity
Humans
Immune Evasion
Phylogeny
Point Mutation
Polymorphism, Single Nucleotide
Rabbits
Staphylococcal Infections
Staphylococcus aureus
Tropism
Animals
Rabbits
Humans
Staphylococcus aureus
Staphylococcal Infections
Evolution, Molecular
Phylogeny
Tropism
Point Mutation
Polymorphism, Single Nucleotide
Genetic Speciation
Immune Evasion
Host Specificity
06 Biological Sciences
11 Medical and Health Sciences
Developmental Biology
Publication Status: Published
Online Publication Date: 2015-02-16
Appears in Collections:Department of Infectious Diseases
Faculty of Medicine