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Multihost transmission of Schistosoma mansoni in Senegal, 2015-2018.

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Title: Multihost transmission of Schistosoma mansoni in Senegal, 2015-2018.
Authors: Catalano, S
Léger, E
Fall, CB
Borlase, A
Diop, SD
Berger, D
Webster, BL
Faye, B
Diouf, ND
Rollinson, D
Sène, M
Bâ, K
Webster, JP
Item Type: Journal Article
Abstract: In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%-44.8% in school-aged children, 1.7%-52.6% in Mastomys huberti mice, and 1.8%-7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13-0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions.
Issue Date: Jun-2020
Date of Acceptance: 1-Jun-2020
URI: http://hdl.handle.net/10044/1/80156
DOI: 10.3201/eid2606.200107
ISSN: 1080-6040
Publisher: U.S. National Center for Infectious Diseases
Start Page: 1234
End Page: 1242
Journal / Book Title: Emerging Infectious Diseases
Volume: 26
Issue: 6
Copyright Statement: © 2020 The Author(s). This an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0, which permits redistribution and copy for non-commercial use, provided the original article is not altered, and the author(s) and source is credited. http://creativecommons.org/licenses/by-nc-nd/3.0/
Keywords: Biomphalaria pfeifferi
Lac de Guiers
Mastomys huberti
One Health
Rodentia
Schistosoma
Schistosoma mansoni
Senegal
Senegal River Basin
West Africa
children
definitive host
evolution
infectious diseases
molecular epidemiology
multihost system
parasites
reservoir
rodents
schistosomiasis
snail
transmission
zoonoses
Biomphalaria pfeifferi
Lac de Guiers
Mastomys huberti
One Health
Rodentia
Schistosoma
Schistosoma mansoni
Senegal
Senegal River Basin
West Africa
children
definitive host
evolution
infectious diseases
molecular epidemiology
multihost system
parasites
reservoir
rodents
schistosomiasis
snail
transmission
zoonoses
1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Microbiology
Publication Status: Published
Conference Place: United States
Online Publication Date: 2020-06-01
Appears in Collections:School of Public Health