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Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Title: Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
Authors: Stephen, R
Liu, Y
Ngandu, T
Antikainen, R
Hulkkonen, J
Koikkalainen, J
Kemppainen, N
Lotjonen, J
Levalahti, E
Parkkola, R
Pippola, P
Rinne, J
Strandberg, T
Tuomilehto, J
Vanninen, R
Kivipelto, M
Soininen, H
Solomon, A
Item Type: Journal Article
Abstract: Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimodal intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports exploratory analyses of brain MRI measures. Methods FINGER targeted 1260 older individuals from the general Finnish population. Participants were 60–77 years old, at increased risk for dementia but without dementia/substantial cognitive impairment. Brain MRI scans were available for 132 participants (68 intervention, 64 control) at baseline and 112 participants (59 intervention, 53 control) at 2 years. MRI measures included regional brain volumes, cortical thickness, and white matter lesion (WML) volume. Cognition was assessed at baseline and 1- and 2-year visits using a comprehensive neuropsychological test battery. We investigated the (1) differences between the intervention and control groups in change in MRI outcomes (FreeSurfer 5.3) and (2) post hoc sub-group analyses of intervention effects on cognition in participants with more versus less pronounced structural brain changes at baseline (mixed-effects regression models, Stata 12). Results No significant differences between the intervention and control groups were found on the changes in MRI measures. Beneficial intervention effects on processing speed were more pronounced in individuals with higher baseline cortical thickness in Alzheimer’s disease signature areas (composite measure of entorhinal, inferior and middle temporal, and fusiform regions). The randomization group × time × cortical thickness interaction coefficient was 0.198 (p = 0.021). A similar trend was observed for higher hippocampal volume (group × time × hippocampus volume interaction coefficient 0.1149, p = 0.085). Conclusions The FINGER MRI exploratory sub-study did not show significant differences between the intervention and control groups on changes in regional brain volumes, regional cortical thicknesses, or WML volume after 2 years in at-risk elderly without substantial impairment. The cognitive benefits on processing speed of the FINGER intervention may be more pronounced in individuals with fewer structural brain changes on MRI at baseline. This suggests that preventive strategies may be more effective if started early, before the occurrence of more pronounced structural brain changes. Trial registration ClinicalTrials.gov, NCT01041989. Registered January 5, 2010.
Issue Date: 4-Jun-2019
Date of Acceptance: 16-May-2019
URI: http://hdl.handle.net/10044/1/79651
DOI: 10.1186/s13195-019-0506-z
ISSN: 1758-9193
Publisher: BMC
Start Page: 1
End Page: 10
Journal / Book Title: Alzheimers Research & Therapy
Volume: 11
Copyright Statement: © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Prevention
Cognitive impairment
Dementia
Randomized controlled trial
Lifestyle
Neuroimaging
DEMENTIA RISK SCORE
ALZHEIMERS-DISEASE
PARTICIPANTS
MEDICINE
PEOPLE
WOMEN
TRIAL
Cognitive impairment
Dementia
Lifestyle
Neuroimaging
Prevention
Randomized controlled trial
Aged
Cerebral Cortex
Cognitive Dysfunction
Disability Evaluation
Female
Finland
Geriatric Assessment
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
FINGER study group
Cerebral Cortex
Humans
Magnetic Resonance Imaging
Disability Evaluation
Organ Size
Geriatric Assessment
Aged
Middle Aged
Finland
Female
Male
Cognitive Dysfunction
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Prevention
Cognitive impairment
Dementia
Randomized controlled trial
Lifestyle
Neuroimaging
DEMENTIA RISK SCORE
ALZHEIMERS-DISEASE
PARTICIPANTS
MEDICINE
PEOPLE
WOMEN
TRIAL
11 Medical and Health Sciences
Publication Status: Published
Article Number: ARTN 53
Online Publication Date: 2019-06-04
Appears in Collections:School of Public Health