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A behavioural approach to specifying interventions: what insights can be gained for the reporting and implementation of interventions to reduce antibiotic use in hospitals?

Title: A behavioural approach to specifying interventions: what insights can be gained for the reporting and implementation of interventions to reduce antibiotic use in hospitals?
Authors: Duncan, EM
Charani, E
Clarkson, JE
Francis, JJ
Gillies, K
Grimshaw, JM
Kern, WV
Lorencatto, F
Marwick, CA
McEwen, J
Möhler, R
Morris, AM
Ramsay, CR
Rogers Van Katwyk, S
Rzewuska, M
Skodvin, B
Smith, I
Suh, KN
Davey, PG
Item Type: Journal Article
Abstract: BACKGROUND: Reducing unnecessary antibiotic exposure is a key strategy in reducing the development and selection of antibiotic-resistant bacteria. Hospital antimicrobial stewardship (AMS) interventions are inherently complex, often requiring multiple healthcare professionals to change multiple behaviours at multiple timepoints along the care pathway. Inaction can arise when roles and responsibilities are unclear. A behavioural perspective can offer insights to maximize the chances of successful implementation. OBJECTIVES: To apply a behavioural framework [the Target Action Context Timing Actors (TACTA) framework] to existing evidence about hospital AMS interventions to specify which key behavioural aspects of interventions are detailed. METHODS: Randomized controlled trials (RCTs) and interrupted time series (ITS) studies with a focus on reducing unnecessary exposure to antibiotics were identified from the most recent Cochrane review of interventions to improve hospital AMS. The TACTA framework was applied to published intervention reports to assess the extent to which key details were reported about what behaviour should be performed, who is responsible for doing it and when, where, how often and with whom it should be performed. RESULTS: The included studies (n = 45; 31 RCTs and 14 ITS studies with 49 outcome measures) reported what should be done, where and to whom. However, key details were missing about who should act (45%) and when (22%). Specification of who should act was missing in 79% of 15 interventions to reduce duration of treatment in continuing-care wards. CONCLUSIONS: The lack of precise specification within AMS interventions limits the generalizability and reproducibility of evidence, hampering efforts to implement AMS interventions in practice.
Issue Date: 1-May-2020
Date of Acceptance: 16-Dec-2019
URI: http://hdl.handle.net/10044/1/79584
DOI: 10.1093/jac/dkaa001
ISSN: 0305-7453
Publisher: Oxford University Press (OUP)
Start Page: 1338
End Page: 1346
Journal / Book Title: Journal of Antimicrobial Chemotherapy
Volume: 75
Issue: 5
Copyright Statement: VCThe Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided theoriginal work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Keywords: 0605 Microbiology
1108 Medical Microbiology
1115 Pharmacology and Pharmaceutical Sciences
Microbiology
Publication Status: Published
Conference Place: England
Online Publication Date: 2020-02-04
Appears in Collections:Department of Infectious Diseases