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Biological materials: the next frontier for cell-free synthetic biology

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Title: Biological materials: the next frontier for cell-free synthetic biology
Authors: Kelwick, R
Webb, A
Freemont, P
Item Type: Journal Article
Abstract: Advancements in cell-free synthetic biology are enabling innovations in sustainable biomanufacturing, that may ultimately shift the global manufacturing paradigm toward localized and ecologically harmonized production processes. Cell-free synthetic biology strategies have been developed for the bioproduction of fine chemicals, biofuels and biological materials. Cell-free workflows typically utilize combinations of purified enzymes, cell extracts for biotransformation or cell-free protein synthesis reactions, to assemble and characterize biosynthetic pathways. Importantly, cell-free reactions can combine the advantages of chemical engineering with metabolic engineering, through the direct addition of co-factors, substrates and chemicals –including those that are cytotoxic. Cell-free synthetic biology is also amenable to automatable design cycles through which an array of biological materials and their underpinning biosynthetic pathways can be tested and optimized in parallel. Whilst challenges still remain, recent convergences between the materials sciences and these advancements in cell-free synthetic biology enable new frontiers for materials research.
Issue Date: 12-May-2020
Date of Acceptance: 8-Apr-2020
URI: http://hdl.handle.net/10044/1/79246
DOI: 10.3389/fbioe.2020.00399
ISSN: 2296-4185
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Bioengineering and Biotechnology
Volume: 8
Copyright Statement: Copyright © 2020 Kelwick, Webb and Freemont. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: EP/P028519/1
EP/R511547/1
EP/L011573/1
BB/L027852/1
Keywords: 0699 Other Biological Sciences
0903 Biomedical Engineering
1004 Medical Biotechnology
Publication Status: Published
Open Access location: https://www.frontiersin.org/articles/10.3389/fbioe.2020.00399/abstract
Article Number: ARTN 399
Online Publication Date: 2020-05-12
Appears in Collections:Department of Infectious Diseases
Faculty of Medicine