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Senescent cells: emerging targets for human aging and age-related diseases

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Title: Senescent cells: emerging targets for human aging and age-related diseases
Authors: Song, S
Lam, E
Tchkonia, T
Kirkland, JL
Sun, Y
Item Type: Journal Article
Abstract: Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
Issue Date: Jul-2020
Date of Acceptance: 6-Apr-2020
URI: http://hdl.handle.net/10044/1/79196
DOI: 10.1016/j.tibs.2020.03.008
ISSN: 0167-7640
Publisher: Elsevier
Start Page: 578
End Page: 592
Journal / Book Title: Trends in Biochemical Sciences
Volume: 45
Issue: 7
Copyright Statement: © 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Cancer Research UK
Breast Cancer Care & Breast Cancer Now
Breast Cancer Care & Breast Cancer Now
Medical Research Council (MRC)
Funder's Grant Number: 12011
2012NovemberPhD016
2012MayPR070
MR/N012097/1
Keywords: SASP
cellular senescence
clinical trials
geroscience
senolytics
Developmental Biology
03 Chemical Sciences
06 Biological Sciences
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2020-04-06
Appears in Collections:Department of Surgery and Cancer
Department of Surgery and Cancer
Faculty of Medicine