Coronavirus mRNA synthesis involves fusion of non‐contiguous sequences
| Publication available at: | https://europepmc.org/article/med/6196191 |
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| Title: | Coronavirus mRNA synthesis involves fusion of non‐contiguous sequences |
| Authors: | SPAAN, W DELIUS, H SKINNER, M ARMSTRONG, J ROTTIER, P SMEEKENS, S VANDERZEIJST, BAM SIDDELL, SG |
| Item Type: | Journal Article |
| Abstract: | Positive‐stranded genomic RNA of coronavirus MHV and its six subgenomic mRNAs are synthesized in the cytoplasm of the host cell. The mRNAs are composed of leader and body sequences which are non‐contiguous on the genome and are fused together in the cytoplasm by a mechanism which appears to involve an unusual and specific ‘polymerase jumping’ event. |
| Issue Date: | 1-Oct-1983 |
| Date of Acceptance: | 1-Oct-1983 |
| URI: | http://hdl.handle.net/10044/1/79081 |
| DOI: | 10.1002/j.1460-2075.1983.tb01667.x |
| ISSN: | 0261-4189 |
| Publisher: | EMBO Press |
| Start Page: | 1839 |
| End Page: | 1844 |
| Journal / Book Title: | The EMBO Journal |
| Volume: | 2 |
| Issue: | 10 |
| Copyright Statement: | © IRL Press Limited, Oxford, England. |
| Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Cell Biology Base Sequence Coronaviridae DNA Genes, Viral Microscopy, Electron Nucleic Acid Hybridization RNA, Messenger RNA, Viral RNA-Directed DNA Polymerase Coronaviridae RNA-Directed DNA Polymerase DNA RNA, Messenger RNA, Viral Microscopy, Electron Nucleic Acid Hybridization Base Sequence Genes, Viral Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Cell Biology 06 Biological Sciences 08 Information and Computing Sciences 11 Medical and Health Sciences Developmental Biology |
| Publication Status: | Published |
| Open Access location: | https://europepmc.org/article/med/6196191 |
| Online Publication Date: | 1983-10-01 |
| Appears in Collections: | Department of Infectious Diseases |