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Determinants of accelerated metabolomic and epigenetic ageing in a UK cohort

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Title: Determinants of accelerated metabolomic and epigenetic ageing in a UK cohort
Authors: Robinson, O
Chadeau Hyam, M
Karaman, I
Climaco Pinto, R
Ala-Korpela, M
Handakas, E
Fiorito, G
Gao, H
Heard, A
Jarvelin, M-R
Lewis, M
Pazoki, R
Polidoro, S
Tzoulaki, I
Wielscher, M
Elliott, P
Vineis, P
Item Type: Journal Article
Abstract: Markers of biological aging have potential utility in primary care and public health. We developed a model of age based on untargeted metabolic profiling across multiple platforms, including nuclear magnetic resonance spectroscopy and liquid chromatography–mass spectrometry in urine and serum, within a large sample (N = 2,239) from the UK Airwave cohort. We validated a subset of model predictors in a Finnish cohort including repeat measurements from 2,144 individuals. We investigated the determinants of accelerated aging, including lifestyle and psychological risk factors for premature mortality. The metabolomic age model was well correlated with chronological age (mean r = .86 across independent test sets). Increased metabolomic age acceleration (mAA) was associated after false discovery rate (FDR) correction with overweight/obesity, diabetes, heavy alcohol use and depression. DNA methylation age acceleration measures were uncorrelated with mAA. Increased DNA methylation phenotypic age acceleration (N = 1,110) was associated after FDR correction with heavy alcohol use, hypertension and low income. In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Issue Date: 15-Jun-2020
Date of Acceptance: 2-Mar-2020
URI: http://hdl.handle.net/10044/1/79004
DOI: 10.1111/acel.13149
ISSN: 1474-9718
Publisher: Wiley Open Access
Start Page: 1
End Page: 13
Journal / Book Title: Aging Cell
Volume: 19
Issue: 6
Copyright Statement: © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Commission of the European Communities
Funder's Grant Number: MR/M501669/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Geriatrics & Gerontology
accelerated aging
affective mood disorders
DNA methylation
molecular biology of aging
risk factors
DNA methylation
accelerated aging
affective mood disorders
molecular biology of aging
risk factors
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2020-05-03
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Faculty of Medicine
Grantham Institute for Climate Change
School of Public Health