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Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial

Title: Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
Authors: White, HD
Steg, PG
Szarek, M
Bhatt, DL
Bittner, VA
Diaz, R
Edelberg, JM
Erglis, A
Goodman, SG
Hanotin, C
Harrington, RA
Jukema, JW
Lopes, RD
Mahaffey, KW
Moryusef, A
Pordy, R
Roe, MT
Sritara, P
Tricoci, P
Zeiher, AM
Schwartz, GG
Aylward, PE
Drexel, H
Sinnaeve, P
Dilic, M
Lopes, RD
Gotcheva, NN
Goodman, SG
Prieto, J-C
Yong, H
Lopez-Jaramillo, P
Pecin, I
Reiner, Z
Ostadal, P
Poulsen, SH
Viigimaa, M
Nieminen, MS
Danchin, N
Chumburidze, V
Marx, N
Liberopoulos, E
Montenegro Valdovinos, PC
Tse, H-F
Kiss, RG
Xavier, D
Zahger, D
Valgimigli, M
Kimura, T
Kim, HS
Kim, S-H
Erglis, A
Laucevicius, A
Kedev, S
Yusoff, K
Ramos Lopez, GA
Alings, M
Halvorsen, S
Correa Flores, RM
Sy, RG
Budaj, A
Morais, J
Dorobantu, M
Karpov, Y
Ristic, AD
Chua, T
Murin, J
Fras, Z
Dalby, AJ
Tunon, J
De Silva, HA
Hagstrom, E
Muller, C
Chiang, C-E
Sritara, P
Guneri, S
Parkhomenko, A
Ray, KK
Moriarty, PM
Vogel, R
Chaitman, B
Kelsey, SF
Olsson, AG
Rouleau, J-L
Simoons, ML
Alexander, K
Meloni, C
Rosenson, R
Sijbrands, EJG
Alexander, JH
Armaganijan, L
Bagai, A
Bahit, MC
Brennan, JM
Clifton, S
DeVore, AD
Deloatch, S
Dickey, S
Dombrowski, K
Ducrocq, G
Eapen, Z
Endsley, P
Eppinger, A
Hess, CN
Hlatky, MA
Jordan, JD
Knowles, JW
Kolls, BJ
Kong, DF
Leonardi, S
Lillis, L
Lopes, RD
Maron, DJ
Marcus, J
Mathews, R
Mehta, RH
Mentz, RJ
Moreira, HG
Patel, CB
Pereira, SB
Perkins, L
Povsic, TJ
Puymirat, E
Jones, WS
Shah, BR
Sherwood, MW
Stringfellow, K
Sujjavanich, D
Toma, M
Trotter, C
Van Diepen, SFP
Wilson, MD
Yan, AT-K
Schiavi, LB
Garrido, M
Alvarisqueta, AF
Sassone, SA
Bordonava, AP
Alves De Lima, AE
Schmidberg, JM
Duronto, EA
Caruso, OC
Novaretto, LP
Angel Hominal, M
Montana, OR
Caccavo, A
Gomez Vilamajo, OA
Lorenzatti, AJ
Cartasegna, LR
Paterlini, GA
Mackinnon, IJ
Caime, GD
Amuchastegui, M
Codutti, OR
Jure, HO
Bono, JOE
Hrabar, AD
Vallejos, JA
Ahuad Guerrero, RA
Novoa, F
Patocchi, CA
Zaidman, CJ
Giuliano, ME
Dran, RD
Vico, ML
Carnero, GS
Guzman, PN
Medrano Allende, JC
Garcia Brasca, DF
Bustamante Labarta, MH
Nani, S
Blumberg, EDS
Colombo, HR
Liberman, A
Luciardi, HL
Waisman, GD
Berli, MA
Garcia Duran, RO
Cestari, HG
Luquez, HA
Giordano, JA
Saavedra, SS
Waites, JH
Collins, N
Soward, A
Hii, CLS
Shaw, J
Arstall, MA
Horowitz, J
Rogers, JF
Colquhoun, D
Flores, REO
Roberts-Thomson, P
Raffel, O
Lehman, SJ
Coverdale, SGM
Garrahy, PJ
Starmer, G
Sader, M
Carroll, PA
Zweiker, R
Hoppe, U
Huber, K
Berger, R
Weidinger, F
Faes, D
Hermans, K
Pirenne, B
Leone, A
Hoffer, E
Vrolix, MCM
De Wolf, L
Wollaert, B
Castadot, M
Dujardin, K
Beauloye, C
Vervoort, G
Striekwold, H
Convens, C
Roosen, J
Barbato, E
Claeys, M
Cools, F
Terzic, I
Barakovic, F
Midzic, Z
Pojskic, B
Fazlibegovic, E
Durak-Nalbantic, A
Vulic, D
Muslibegovic, A
Reis, G
Sousa, L
Nicolau, JC
Giorgeto, FE
Silva, RP
Maia, LN
Rech, R
Rossi, PRF
Cerqueira, MJAG
Duda, N
Kalil, R
Kormann, A
Abrantes, JAM
Pimentel Filho, P
Soggia, AP
De Santos, MON
Neuenschwander, F
Bodanese, LC
Michalaros, YL
Eliaschewitz, FG
Vidotti, MH
Leaes, PE
Botelho, RV
Kaiser, S
Fernandes Manenti, ERF
Precoma, DB
Moura Jorge, JC
Silva, PGMDB
Silveira, JA
Saporito, W
Marin Neto, JA
Feitosa, GS
Ritt, LEF
De Souza, JA
Costa, F
Souza, WKSB
Reis, HJL
Lopes, RD
Machado, L
Aidar Ayoub, JC
Todorov, GV
Nikolov, FP
Velcheva, ES
Tzekova, ML
Benov, HO
Petranov, SL
Tumbev, HS
Shehova-Yankova, NS
Markov, DT
Raev, DH
Mollov, MN
Kichukov, KN
Ilieva-Pandeva, KA
Gotcheva, NN
Ivanova, R
Mincheva, VM
Lazov, PV
Dimov, BI
Senaratne, M
Stone, J
Kornder, J
Pearce, S
Dion, D
Savard, D
Pesant, Y
Pandey, A
Robinson, S
Gosselin, G
Vizel, S
Hoag, G
Bourgeois, R
Morisset, A
Sabbah, E
Sussex, B
Kouz, S
MacDonald, P
Diaz, A
Michaud, N
Fell, D
Leung, R
Vuurmans, T
Lai, C
Nigro, F
Davies, R
Nogareda, G
Vijayaraghavan, R
Ducas, J
Lepage, S
Mehta, S
Cha, J
Dupuis, R
Fong, P
Rodes-Cabau, J
Fadlallah, H
Cleveland, D
Huynh, T
Bata, I
Hameed, A
Pincetti, C
Potthoff, S
Acevedo, M
Aguirre, A
Vejar, M
Yanez, M
Araneda, G
Fernandez, M
Perez, L
Varleta, P
Florenzano, F
Huidobro, L
Raffo, CA
Olivares, C
Chen, J
Dong, Y
Huang, W
Wang, J
Huang, S
Yao, Z
Cui, L
Lin, W
Sun, Y
Wang, J
Li, J
Zhang, X
Zhu, H
Chen, D
Huang, L
Dong, S
Su, G
Xu, B
Su, X
Cheng, X
Lin, J
Zong, W
Li, H
Feng, Y
Xu, D
Yang, X
Ke, Y
Lin, X
Zhang, Z
Zheng, Z
Luo, Z
Chen, Y
Ding, C
Zheng, Y
Li, X
Peng, D
Li, Y
Wei, M
Liu, S
Yu, Y
Qu, B
Jiang, W
Zhou, Y
Zhao, X
Yuan, Z
Guo, Y
Xu, X
Shi, X
Ge, J
Fu, G
Bai, F
Fang, W
Shou, X
Yang, X
Wang, J
Jaramillo, N
Vallejo, GS
Botia, DCL
Lopez, RB
De Salazar, DIM
Bonfanti, AJC
Higuera, JD
Silva, SIB
Lozada, HJG
Arroyo, JAC
Mendoza, JLA
Ruiz, RLF
Fernandez, AM
Jatin, FGM
Herazo, AS
Parada, JC
Triana, MAU
Spinar, J
Horak, D
Stasek, J
Alan, D
Machova, V
Linhart, A
Novotny, V
Kaucak, V
Rokyta, R
Naplava, R
Coufal, Z
Adamkova, V
Podpera, I
Zizka, J
Motovska, Z
Marusincova, I
Svab, P
Heinc, P
Kuchar, J
Povolny, P
Raungaard, B
Clemmensen, P
Bang, LE
May, O
Bottcher, M
Hove, JD
Frost, L
Gislason, G
Larsen, J
Johansen, PB
Hald, F
Jeppesen, J
Nielsen, T
Kristensen, KS
Walichiewicz, PM
Lomholdt, JD
Klausen, IC
Nielsen, PK
Davidsen, F
Videbaek, L
Soots, M
Vahula, V
Hedman, A
Soopold, S
Martsin, K
Taskinen, M-R
Porthan, K
Airaksinen, JK
Juonala, M
Kiviniemi, T
Vikman, S
Posio, P
Taurio, J
Huikuri, H
Kaikkonen, K
Coste, P
Ferrari, E
Morel, O
Montalescot, G
Barone-Rochette, G
Mansourati, J
Cottin, Y
Steg, PG
Leclercq, F
Belhassane, A
Delarche, N
Boccara, F
Paganelli, F
Clerc, J
Schiele, F
Aboyans, V
Probst, V
Berland, J
Lefevre, T
Khintibidze, I
Shaburishvili, T
Pagava, Z
Ghlonti, R
Lominadze, Z
Khabeishvili, G
Hemetsberger, R
Rauch-Kroehnert, U
Stratmann, M
Appel, K-F
Schmidt, E
Omran, H
Stellbrink, C
Dorsel, T
Lianopoulos, E
Marx, R
Zirlik, A
Schellenberg, D
Heitzer, T
Laufs, U
Marx, N
Gielen, S
Winkelmann, B
Behrens, S
Sydow, K
Simonis, G
Muenzel, T
Werner, N
Leggewie, S
Boecker, D
Braun-Dullaeus, R
Toursarkissian, N
Jeserich, M
Weissbrodt, M
Schaeufele, T
Weil, J
Voeller, H
Waltenberger, J
Natour, M
Steiner, S
Heidenreich, L
Gremmler, U
Killat, H
Patsilinakos, S
Kartalis, A
Manolis, A
Sionis, D
Liberopoulos, E
Skoumas, I
Athyros, V
Parthenakis, PIF
Hahalis, PIG
Lekakis, J
Xatzitolios, A
Fausto Ovando, SR
Montenegro Valdovinos, PC
Arango Benecke, JL
Rodriguez De Leon, ER
Yan, BPY
Siu, DCW
Turi, T
Merkely, B
Kiss, RG
Ungi, I
Lupkovics, G
Nagy, L
Katona, A
Edes, I
Muller, G
Horvath, I
Kapin, T
Falukozy, J
Kumbla, M
Sandhu, M
Annam, S
Proddutur, NR
Premchand, RK
Mahajan, A
Abhyanakar, AD
Kerkar, P
Govinda, RA
Oomman, A
Sinha, D
Patil, SN
Kahali, D
Sawhney, J
Joshi, AB
Chaudhary, S
Harkut, P
Guha, S
Porwal, S
Jujjuru, S
Pothineni, RB
Monteiro, MR
Khan, A
Iyengar, SS
Grewal, JS
Chopda, M
Fulwani, MC
Patange, A
Chopra, VK
Goyal, NK
Shinde, R
Manakshe, GV
Patki, N
Sethi, S
Munusamy, V
Karna, S
Adhyapak, S
Pandurangi, U
Mathur, R
Kalashetti, S
Bhagwat, A
Raghuraman, B
Yerra, SK
Bhansali, P
Borse, R
Das, S
Abdullakutty, J
Saathe, S
Palimkar, P
Atar, S
Shechter, M
Mosseri, M
Arbel, Y
Lotan, C
Rosenschein, U
Katz, A
Henkin, Y
Francis, A
Klutstein, M
Nikolsky, E
Turgeman, Y
Halabi, M
Kornowski, R
Jonas, M
Amir, O
Rozenman, Y
Fuchs, S
Hussein, O
Gavish, D
Vered, Z
Caraco, Y
Elias, M
Tov, N
Piovaccari, G
De Pellegrin, A
Guardigli, G
Licciardello, G
Auguadro, C
Cuccia, C
Salvioni, A
Musumeci, G
Calabro, P
Novo, S
Faggiano, P
De Cesare, NB
Berti, S
Cavallini, C
Puccioni, E
Galvani, M
Tespili, M
Piatti, P
Palvarini, M
De Luca, G
Violini, R
De Leo, A
Filardi, PP
Ferratini, M
Dai, K
Kamiya, H
Ando, K
Takeda, Y
Morino, Y
Hata, Y
Kimura, K
Kishi, K
Michishita, I
Uehara, H
Higashikata, T
Hirayama, A
Hirooka, K
Sakagami, S
Taguchi, S
Koike, A
Fujinaga, H
Koba, S
Kozuma, K
Kawasaki, T
Ono, Y
Shimizu, M
Katsuda, Y
Wada, A
Shinke, T
Ako, J
Fujii, K
Takahashi, T
Sakamoto, T
Furukawa, Y
Sugino, H
Mano, T
Utsu, N
Ito, K
Haraguchi, T
Ueda, Y
Nishibe, A
Fujimoto, K
Yoon, JH
Park, HS
Chae, I-H
Kim, MH
Jeong, MH
Rha, S
Kim, C
Hong, T
Busmane, A
Pontaga, N
Strelnieks, A
Mintale, I
Sime, I
Petrulioniene, Z
Kavaliauskiene, R
Jurgaitiene, R
Sakalyte, G
Slapikas, R
Norkiene, S
Misonis, N
Kibarskis, A
Kubilius, R
Bojovski, S
Lozance, N
Kjovkaroski, A
Doncovska, S
Ong, TK
Kasim, S
Maskon, O
Kandasamy, B
Liew, HB
Mohamed, WMIW
Garcia Castillo, A
Carrillo Calvillo, J
Fajardo Campos, P
Nunez Fragoso, JC
Bayram Llamas, EA
Alcocer Gamba, MA
Carranza Madrigal, J
Gonzalez Salas, LG
Lopez Rosas, E
Gonzalez Diaz, B
Salcido Vazquez, E
Nacoud Ackar, A
Llamas Esperon, GA
Martinez Sanchez, CR
Guerrero De Leon, M
Suarez Otero, R
Fanghanel Salmon, G
Perez Rios, JA
Garza Ruiz, JA
Breedveld, RW
Hoogslag, PAM
Suryapranata, H
Oomen, A
Wiersma, JJ
Van Der Wal, RMA
Van Huysduynen-Monraats, PSH
Karalis, I
Verdel, GJE
Brueren, BRG
Troquay, RPT
Viergever, EP
Al-Windy, NYY
Bartels, GL
Cornel, JH
Hermans, WRM
Herrman, JPR
Bos, RJ
Groutars, RGEJ
Van Der Zwaan, CC
Kaplan, R
Ronner, E
Groenemeijer, BE
Bronzwaer, PNA
Liem, AAH
Rensing, BJWM
Bokern, MJJA
Nijmeijer, R
Hersbach, FMRJ
Willems, FF
Gosselink, ATM
Elliott, J
Wilkins, G
Fisher, R
Scott, D
Hart, H
Stewart, R
Harding, S
Ternouth, I
Fisher, N
Aitken, D
Anscombe, R
Tomala, T
Nygard, O
Sparby, JA
Andersen, K
Gullestad, L
Jortveit, J
Munk, PS
Hurtig, U
Ticona, JRC
Velasquez, JRD
Miguel, SAN
Perez, ESS
Chambilla, JMC
Ayala, CAC
Leon, RPC
Gonzales, RJV
Zuniga, JDH
Cosavalente, LAC
Mannucci, JEB
Navarro, NCL
Concha, YMR
Chavez, V-CER
Hernandez, HAA
Nunez, CAZ
Ferrolino, A
Sy, RAG
Tirador, L
Matiga, G
Coching, RM
Bernan, A
Rogelio, G
Morales, DD
Tan, E
Wlodarczak, A
Jaworska, K
Skonieczny, G
Pawlowicz, L
Wojewoda, P
Busz-Papiez, B
Bednarski, J
Goch, A
Staneta, P
Dulak, E
Saminski, K
Krasowski, W
Sudnik, W
Zurakowski, A
Skorski, M
Lysek, R
Miklaszewicz, B
Kubica, J
Lipko, JA
Kostarska-Srokosz, E
Piepiorka, M
Drzewiecka, A
Sciborski, R
Stasiewski, A
Blicharski, T
Bystryk, L
Szpajer, M
Korol, M
Czerski, T
Mirek-Bryniarska, E
Gniot, J
Lubinski, A
Gorny, J
Franek, E
Monteiro, P
Bastos, JM
Pereira, HH
Martins, D
Seixo, F
Mendonca, C
Botelho, A
Minescu, B
Istratoaie, O
Tesloianu, DN
Cristian, G
Podoleanu, CGC
Constantinescu, MCA
Bengus, CM
Militaru, C
Rosu, D
Parepa, IR
Matei, AV
Alexandru, TM
Shvarts, Y
Orlikova, O
Kobalava, Z
Barbarash, OL
Markov, V
Lyamina, N
Gordienko, A
Zrazhevsky, K
Vishnevsky, AY
Gurevich, V
Stryuk, R
Lomakin, NV
Bokarev, I
Shalaev, S
Khaisheva, L
Chizhov, P
Viktorova, I
Osokina, N
Akatova, E
Chumakova, G
Libov, I
Voevoda, MI
Tretyakova, TV
Baranov, E
Shustov, S
Yakushin, S
Gordeev, I
Khasanov, N
Reshetko, O
Sotnikova, T
Molchanova, O
Nikolaev, K
Gapon, L
Baranova, E
Shogenov, Z
Kosmachova, E
Karpov, Y
Povzun, A
Egorova, L
Tyrenko, VV
Ivanov, IG
Simic, D
Ivanovic, N
Davidovic, G
Tasic, N
Asanin, MR
Stojic, S
Apostolovic, SR
Ilic, S
Putnikovic, B
Stankovic, A
Arandjelovic, A
Radovanovic, S
Balinovac, J
Dincic, DV
Seferovic, P
Dodic, S
Dimkovic, S
Poh, K-K
Ong, HY
Micko, K
Nociar, J
Pella, D
Fulop, P
Hranai, M
Palka, J
Mazur, J
Majercak, I
Dzupina, A
Fazekas, F
Gonsorcik, J
Bugan, V
Selecky, J
Kamensky, G
Strbova, J
Smik, R
Dukat, A
Zuran, I
Oklukar, J
Suligoj, NC
Cevc, M
Lipar, L
Cyster, HP
Ranjith, N
Corbett, C
Bayat, J
Makotoko, EM
Kapp, IE
Basson, MMDV
Lottering, H
Van Zyl, LJ
Sebastian, PJ
Pillay, T
Saaiman, JA
Commerford, PJ
Cassimjee, S
Ebrahim, IO
Sarvan, M
Mynhardt, JH
Dalby, AJ
Reuter, H
Moodley, R
Vida, M
Cequier Fillat, AR
Bodi Peris, V
Fuentes Jimenez, F
Marin, F
Cruz Fernandez, JM
Gil-Extremera, B
Worner Diz, F
Garcia-Dorado, D
Iniguez, A
Tunon Fernandez, J
Gonzalez-Juanatey, JR
Fernandez Portales, J
Civeira Murillo, F
Matas Pericas, L
Luis Zamorano, J
De Mora Martin, M
Bruguera Cortada, J
Alonso Martin, JJ
De Berrazueta Fernandez, JR
Diaz Fernandez, JF
Garcia Lledo, JA
Cosin Sales, J
Botas Rodriguez, J
Gusi Tragant, G
Benedicto, A
Gonzalez-Juanatey, C
Camprubi Potau, M
Plaza Perez, I
Moris De La Tassa, C
Loma-Osorio Rincon, P
Balaguer Recena, J
M Escudier, J
Constantine, G
Haniffa, R
Tissera, N
Amarasekera, S
Fernando, N
Jayawardena, J
Santharaj, W
Ekanayaka, R
Mendis, S
Senaratne, V
Mayurathan, G
Sirisena, T
Rajapaksha, A
Herath, JI
Amarasena, N
Berglund, S
Rasmanis, G
Hagstrom, E
Witt, N
Mourtzinis, G
Nicol, P
Hansen, O
Romeo, S
Jensen, SA
Torstensson, I
Jensen, SA
Ahremark, U
Sundelin, T
Moccetti, T
Mueller, C
Mach, F
Binder, R
Chiang, C-E
Tsai, W-C
Ueng, K-C
Lai, W-T
Liu, M-E
Hwang, J-J
Yin, W-H
Hsieh, I-C
Lin, WH
Kuo, J-Y
Huang, T-Y
Fang, C-Y
Kaewsuwanna, P
Soonfuang, W
Jintapakorn, W
Sukonthasarn, A
Sritara, P
Wongpraparut, N
Sastravaha, K
Sansanayudh, N
Kehasukcharoen, W
Piyayotai, D
Camsari, A
Kultursay, H
Guneri, S
Mutlu, B
Ersanli, M
Demirtas, M
Kirma, C
Ural, E
Koldas, L
Karpenko, O
Prokhorov, A
Vakaluyk, I
Myshanych, H
Reshotko, D
Batushkin, V
Rudenko, L
Kovalskyi, I
Kushnir, M
Tseluyko, V
Mostovoy, Y
Stanislavchuk, M
Kyiak, Y
Karpenko, Y
Malynovsky, Y
Klantsa, A
Kutniy, O
Amosova, E
Tashchuk, V
Leshchuk, O
Parkhomenko, A
Rishko, M
Kopytsya, M
Yagensky, A
Vatutin, M
Bagriy, A
Barna, OM
Ushakov, O
Dzyak, G
Goloborodko, B
Rudenko, A
Trevelyan, J
Zaman, A
Lee, K
Moriarty, A
Aggarwal, RK
Clifford, P
Wong, Y-K
Iqbal, SMR
Subkovas, E
Braganza, D
Sarkar, D
Storey, R
Griffiths, H
Mcclure, S
Muthusamy, R
Kurian, J
Levy, T
Barr, C
Kadr, H
Gerber, R
Simaitis, A
Soran, H
Mathur, A
Brodison, A
Oliver, R
Mudawi, T
Reynolds, T
Sharman, D
Butler, R
Wilkinson, P
Lip, GYH
Halcox, J
Vardi, G
Baldari, D
Brabham, D
Treasure, C
Dahl, C
Palmer, B
Wiseman, A
Khan, A
Puri, S
Mohart, AE
Ince, C
Flores, E
Wright, S
Cheng, S-C
Rosenberg, M
Rogers, W
Kosinski, E
Forgosh, L
Waltman, J
Khan, M
Shoukfeh, M
Dagher, G
Lieber, I
Kumar, P
East, C
Krichmar, P
White, L
Knickelbine, T
Haldis, T
Gillespie, E
Suh, D
Arif, I
Akhter, F
Carlson, E
D'Urso, M
El-Ahdab, F
Nelson, W
Harris, B
Cohen, S
Carter, L
Sabatino, K
Haddad, T
Malik, A
Rao, S
Mulkay, A
Jovin, I
Klancke, K
Malhotra, V
Devarapalli, SK
Koren, M
Chandna, H
Dodds, G
Janik, M
Moran, J
Sumner, A
Kobayashi, J
Davis, W
Yazdani, S
Pasquini, J
Thakkar, M
Vedere, A
Leimbach, W
Rider, J
Singh, N
Shah, AV
Moriarty, PM
Janosik, D
Pepine, C
Berman, B
Gelormini, J
Daniels, C
Keating, F
Kondo, NI
Shetty, S
Waider, W
Takata, T
Abu-Fadel, M
Shah, V
Aggarwal, R
Izzo, M
Kumar, A
Hattler, B
Link, C
Bortnick, A
Kinzfogl, G
Ghitis, A
Larry, J
Teufel, E
Kuhlman, P
Mclaurin, B
Zhang, W
Thew, S
Abbas, J
White, M
Ranadive, N
Gring, C
Henderson, D
Schuchard, T
Farhat, N
Kline, G
Mahal, S
Whitaker, J
Speirs, S
Andersen, R
Daboul, N
Horwitz, P
Jafar, Z
Mcgarvey, J
Panchal, V
Voyce, S
Blok, T
Sheldon, W
Azizad, MM
Schmalfuss, C
Picone, M
Herzog, W
Lindsey, J
Nowins, R
Lepor, N
El Shahawy, M
Weintraub, H
Irimpen, A
May, W
Galski, T
Chu, A
Mody, F
Hodes, Z
Fairlamb, J
Lambert, C
Raisinghani, A
Abbate, A
King, M
Carey, C
Gerber, J
Younis, L
Park, HT
Vidovich, M
Knutson, T
Friedman, D
Chaleff, F
Loussararian, A
Kimmelstiel, C
Silver, K
Foster, M
Tonnessen, G
Amlani, M
Wali, A
Malozzi, C
Wattanakit, K
O'Donnell, PJ
Singal, D
Jaffrani, N
Banuru, S
Fisher, D
Xenakis, M
Perlmutter, N
Bhagwat, R
Strader, J
Akyea-Djamson, A
Labroo, A
Lee, K
Marais, HJ
Claxton, E
Berk, M
Rossi, P
Joshi, P
Khaira, AS
Kumkumian, G
Lupovitch, S
Purow, J
Welka, S
Hoffman, D
Fischer, S
Soroka, E
Eagerton, D
Pancholy, S
Ray, M
Farrar, M
Pollock, S
French, WJ
Diamantis, S
Gimple, L
Schwartz, S
Pereira, E
Spriggs, D
Strain, J
Vo, A
Chane, M
Hall, J
Vijay, N
Lotun, K
Lester, FM
Nahhas, A
Pope, T
Nager, P
Vohra, R
Bashir, R
Ahmed, H
Berlowitz, M
Fishberg, R
Barrucco, R
Yang, E
Radin, M
Sporn, D
Eisenberg, S
Landzberg, J
Mcgough, M
Turk, S
Schwartz, M
Sundram, PS
Jain, D
Zainea, M
Bayron, C
Karlsberg, R
Lui, H
Keen, W
Westerhausen, D
Khurana, S
Agarwal, H
Birchem, J
Penny, W
Chang, M
Gilbert, JM
Chalavarya, G
Eaton, C
Schmedtje, JF
Christenson, S
Denham, D
Macdonell, A
Gibson, P
Rahman, A
Al Joundi, T
Conrad, G
Kotha, P
Love, M
Giesler, G
Rubenstein, H
Akright, L
Schifferdecker, B
Krawczyk, J
Wells, T
Welker, J
Foster, R
Gilmore, R
Anderson, J
Jacoby, D
Harris, B
Gardner, G
Dandillaya, R
Vora, K
Kostis, J
Hunter, J
Laxson, D
Ball, E
Item Type: Journal Article
Abstract: Aims  The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results  Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion  After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.
Issue Date: 1-Sep-2019
Date of Acceptance: 24-Apr-2019
URI: http://hdl.handle.net/10044/1/78926
DOI: 10.1093/eurheartj/ehz299
ISSN: 0195-668X
Publisher: Oxford University Press (OUP)
Start Page: 2801
End Page: 2809
Journal / Book Title: European Heart Journal
Volume: 40
Issue: 33
Copyright Statement: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Alirocumab
Prevention
MI types
Mortality
UNIVERSAL DEFINITION
METAANALYSIS
CLASSIFICATION
CHOLESTEROL
EVOLOCUMAB
THERAPY
DISEASE
Alirocumab
MI types
Mortality
Prevention
ODYSSEY OUTCOMES Investigators
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Alirocumab
Prevention
MI types
Mortality
UNIVERSAL DEFINITION
METAANALYSIS
CLASSIFICATION
CHOLESTEROL
EVOLOCUMAB
THERAPY
DISEASE
1102 Cardiorespiratory Medicine and Haematology
1103 Clinical Sciences
Cardiovascular System & Hematology
Publication Status: Published
Online Publication Date: 2019-05-23
Appears in Collections:National Heart and Lung Institute