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Genome-wide expression in neonatal encephalopathy

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Title: Genome-wide expression in neonatal encephalopathy
Authors: Montaldo, Paolo
Item Type: Thesis or dissertation
Abstract: Developing new treatments for babies with birth asphyxia related brain injury (neonatal encephalopathy) and preventing cerebral palsy is hampered by two major roadblocks. Firstly, different babies with birth asphyxia may appear clinically similar, but their brain injury may be due to different underlying reasons and they may have different outcomes. Secondly, it takes several years before the impact of brain injury becomes measurable through clinical testing. In my thesis, I examine two key hypotheses (a) cerebral magnetic resonance biomarkers during the neonatal period can accurately predict neurodevelopmental outcomes at 2 years following therapeutic hypothermia for neonatal encephalopathy (b) neonatal encephalopathy is associated with a unique host gene expression profile at the time of birth.
Content Version: Open Access
Issue Date: Dec-2018
Date Awarded: Mar-2019
URI: http://hdl.handle.net/10044/1/78568
DOI: https://doi.org/10.25560/78568
Copyright Statement: Creative Commons Attribution NonCommercial Licence
Supervisor: Thayyil, Sudhin
Mandic, Danilo
Sponsor/Funder: Medical Research Council (Great Britain)
Funder's Grant Number: MR/R001375/1
Department: Department of Medicine
Publisher: Imperial College London
Qualification Level: Doctoral
Qualification Name: Doctor of Philosophy (PhD)
Appears in Collections:Medicine PhD theses