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Autopsy in adults with congenital heart disease (ACHD).

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Title: Autopsy in adults with congenital heart disease (ACHD).
Authors: Angelini, A
Di Gioia, C
Doran, H
Fedrigo, M
Henriques de Gouveia, R
Ho, SY
Leone, O
Sheppard, MN
Thiene, G
Dimopoulos, K
Mulder, B
Padalino, M
Van der Wal, AC
Association for European Cardiovascular Pathology (AECVP)
Item Type: Journal Article
Abstract: The adult congenital heart diseases (ACHD) population is exceeding the pediatric congenital heart diseases (CHD) population and is progressively expanding each year, representing more than 90% of patients with CHD. Of these, about 75% have undergone surgical and/or percutaneous intervention for palliation or correction. Autopsy can be a very challenging procedure in ACHD patients. The approach and protocol to be used may vary depending on whether the pathologists are facing native disease without surgical or percutaneous interventions, but with various degrees of cardiac remodeling, or previously palliated or corrected CHD. Moreover, interventions for the same condition have evolved over the last decades, as has perioperative myocardial preservations and postoperative care, with different long-term sequelae depending on the era in which patients were operated on. Careful clinicopathological correlation is, thus, required to assist the pathologist in performing the autopsy and reaching a diagnosis regarding the cause of death. Due to the heterogeneity of the structural abnormalities, and the wide variety of surgical and interventional procedures, there are no standard methods for dissecting the heart at autopsy. In this paper, we describe the most common types of CHDs that a pathologist could encounter at autopsy, including the various types of surgical and percutaneous procedures and major pathological manifestations. We also propose a practical systematic approach to the autopsy of ACHD patients.
Issue Date: 7-Apr-2020
Date of Acceptance: 8-Jan-2020
URI: http://hdl.handle.net/10044/1/78175
DOI: 10.1007/s00428-020-02779-8
ISSN: 0945-6317
Publisher: Springer Verlag
Start Page: 797
End Page: 820
Journal / Book Title: Virchows Archiv: an international journal of pathology
Volume: 476
Copyright Statement: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology
Life Sciences & Biomedicine
Pathology
Autopsy
Cardiovascular pathology
Congenital heart diseases
Adult congenital heart diseases
Protocol
ATRIAL SEPTAL-DEFECT
SUDDEN CARDIAC DEATH
CORONARY-ARTERY ANOMALIES
SCIENTIFIC STATEMENT
FOLLOW-UP
POSITION STATEMENT
SURGICAL PATHOLOGY
GREAT-ARTERIES
YOUNG-ADULTS
TETRALOGY
Adult congenital heart diseases
Autopsy
Cardiovascular pathology
Congenital heart diseases
Protocol
Association for European Cardiovascular Pathology (AECVP)
Adult congenital heart diseases
Autopsy
Cardiovascular pathology
Congenital heart diseases
Protocol
Pathology
1103 Clinical Sciences
Publication Status: Published
Conference Place: Germany
Online Publication Date: 2020-04-07
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine