A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

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Title: A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
Authors: Kounde, C
Shchepinova, M
Saunders, C
Muelbaier, M
Rackham, M
Harling, J
Tate, E
Item Type: Journal Article
Abstract: With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.
Issue Date: 21-May-2020
Date of Acceptance: 31-Mar-2020
DOI: 10.1039/D0CC00523A
ISSN: 1359-7345
Publisher: Royal Society of Chemistry
Start Page: 5532
End Page: 5535
Journal / Book Title: Chemical Communications
Volume: 56
Issue: 41
Copyright Statement: © The Royal Society of Chemistry 2020.
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: BB/N016947/1
Keywords: Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Online Publication Date: 2020-04-03
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
Faculty of Natural Sciences