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A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
| File | Description | Size | Format | |
|---|---|---|---|---|
 Kounde et al Chem Comm_v2_revised 210320_final.docx | Accepted version | 4.86 MB | Microsoft Word | View/Open |
| Supp info_ Kounde et al. Caged PROTAC_Chem Comm_v2 revised(1).docx | Supporting information | 6.89 MB | Microsoft Word | View/Open |
| Title: | A caged E3 ligase ligand for PROTAC-mediated protein degradation with light |
| Authors: | Kounde, C Shchepinova, M Saunders, C Muelbaier, M Rackham, M Harling, J Tate, E |
| Item Type: | Journal Article |
| Abstract: | With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy. |
| Issue Date: | 21-May-2020 |
| Date of Acceptance: | 31-Mar-2020 |
| URI: | http://hdl.handle.net/10044/1/77762 |
| DOI: | 10.1039/D0CC00523A |
| ISSN: | 1359-7345 |
| Publisher: | Royal Society of Chemistry |
| Start Page: | 5532 |
| End Page: | 5535 |
| Journal / Book Title: | Chemical Communications |
| Volume: | 56 |
| Issue: | 41 |
| Copyright Statement: | © The Royal Society of Chemistry 2020. |
| Sponsor/Funder: | Biotechnology and Biological Sciences Research Council (BBSRC) Biotechnology and Biological Sciences Research Council (BBSRC) |
| Funder's Grant Number: | BB/N016947/1 BB/S001565/1 |
| Keywords: | Organic Chemistry 03 Chemical Sciences |
| Publication Status: | Published |
| Online Publication Date: | 2020-04-03 |
| Appears in Collections: | Chemistry Biological and Biophysical Chemistry Faculty of Natural Sciences |