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Discovery of pre-therapy 2-deoxy-2-F-18-fluoro-D-glucose positron emission tomography-based radiomics classifiers of survival outcome in non-small-cell lung cancer patients

Title: Discovery of pre-therapy 2-deoxy-2-F-18-fluoro-D-glucose positron emission tomography-based radiomics classifiers of survival outcome in non-small-cell lung cancer patients
Authors: Arshad, MA
Thornton, A
Lu, H
Tam, H
Wallitt, K
Rodgers, N
Scarsbrook, A
McDermott, G
Cook, GJ
Landau, D
Chua, S
O'Connor, R
Dickson, J
Power, DA
Barwick, TD
Rockall, A
Aboagye, EO
Item Type: Journal Article
Abstract: Purpose The aim of this multi-center study was to discover and validate radiomics classifiers as image-derived biomarkers for risk stratification of non-small-cell lung cancer (NSCLC). Patients and methods Pre-therapy PET scans from a total of 358 Stage I–III NSCLC patients scheduled for radiotherapy/chemo-radiotherapy acquired between October 2008 and December 2013 were included in this seven-institution study. A semi-automatic threshold method was used to segment the primary tumors. Radiomics predictive classifiers were derived from a training set of 133 scans using TexLAB v2. Least absolute shrinkage and selection operator (LASSO) regression analysis was used for data dimension reduction and radiomics feature vector (FV) discovery. Multivariable analysis was performed to establish the relationship between FV, stage and overall survival (OS). Performance of the optimal FV was tested in an independent validation set of 204 patients, and a further independent set of 21 (TESTI) patients. Results Of 358 patients, 249 died within the follow-up period [median 22 (range 0–85) months]. From each primary tumor, 665 three-dimensional radiomics features from each of seven gray levels were extracted. The most predictive feature vector discovered (FVX) was independent of known prognostic factors, such as stage and tumor volume, and of interest to multi-center studies, invariant to the type of PET/CT manufacturer. Using the median cut-off, FVX predicted a 14-month survival difference in the validation cohort (N = 204, p = 0.00465; HR = 1.61, 95% CI 1.16–2.24). In the TESTI cohort, a smaller cohort that presented with unusually poor survival of stage I cancers, FVX correctly indicated a lack of survival difference (N = 21, p = 0.501). In contrast to the radiomics classifier, clinically routine PET variables including SUVmax, SUVmean and SUVpeak lacked any prognostic information. Conclusion PET-based radiomics classifiers derived from routine pre-treatment imaging possess intrinsic prognostic information for risk stratification of NSCLC patients to radiotherapy/chemo-radiotherapy.
Issue Date: 1-Feb-2019
Date of Acceptance: 16-Aug-2018
URI: http://hdl.handle.net/10044/1/77698
DOI: 10.1007/s00259-018-4139-4
ISSN: 0340-6997
Publisher: Springer Verlag
Start Page: 455
End Page: 466
Journal / Book Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 46
Issue: 2
Copyright Statement: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Cancer Research UK
Funder's Grant Number: RDC04 79560
RDC04
16584
Keywords: Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
Radiomics
NSCLC
Survival
PET
Risk stratification
ED AMERICAN-COLLEGE
FDG-PET
TEXTURAL FEATURES
TUMOR VOLUME
HETEROGENEITY
RADIOTHERAPY
PREDICTION
VARIABILITY
PARAMETERS
MANAGEMENT
NSCLC
PET
Radiomics
Risk stratification
Survival
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
Female
Fluorodeoxyglucose F18
Humans
Image Processing, Computer-Assisted
Lung Neoplasms
Male
Middle Aged
Positron Emission Tomography Computed Tomography
Survival Analysis
Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Fluorodeoxyglucose F18
Survival Analysis
Image Processing, Computer-Assisted
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Positron Emission Tomography Computed Tomography
Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
Radiomics
NSCLC
Survival
PET
Risk stratification
ED AMERICAN-COLLEGE
FDG-PET
TEXTURAL FEATURES
TUMOR VOLUME
HETEROGENEITY
RADIOTHERAPY
PREDICTION
VARIABILITY
PARAMETERS
MANAGEMENT
Nuclear Medicine & Medical Imaging
0299 Other Physical Sciences
1103 Clinical Sciences
Publication Status: Published
Online Publication Date: 2018-09-01
Appears in Collections:Department of Surgery and Cancer