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Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing

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Title: Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing
Authors: James, SL
Marshall, JM
Christophides, GK
Okumu, FO
Nolan, T
Item Type: Journal Article
Abstract: Mosquitoes containing gene drive systems are being developed as complementary tools to prevent transmission of malaria and other mosquito-borne diseases. As with any new tool, decision makers and other stakeholders will need to balance risks (safety) and benefits (efficacy) when considering the rationale for testing and deploying gene drive-modified mosquito products. Developers will benefit from standards for judging whether an investigational gene drive product meets acceptability criteria for advancing to field trials. Such standards may be formalized as preferred product characteristics and target product profiles, which describe the desired attributes of the product category and of a particular product, respectively. This report summarizes discussions from two scientific workshops aimed at identifying efficacy and safety characteristics that must be minimally met for an investigational gene drive-modified mosquito product to be deemed viable to move from contained testing to field release and the data that will be needed to support an application for first field release.
Issue Date: 1-Apr-2020
Date of Acceptance: 1-Feb-2020
URI: http://hdl.handle.net/10044/1/77643
DOI: 10.1089/vbz.2019.2606
ISSN: 1530-3667
Publisher: Mary Ann Liebert
Start Page: 237
End Page: 251
Journal / Book Title: Vector-Borne and Zoonotic Diseases
Volume: 20
Issue: 4
Copyright Statement: © Stephanie L. James et al. 2020; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Infectious Diseases
mosquito
malaria
gene drive
efficacy
biosafety
MALARIA MOSQUITO
PROBLEM FORMULATION
ANOPHELES-GAMBIAE
TRANSMISSION
ELIMINATION
INFECTION
DYNAMICS
VECTORS
FITNESS
Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Infectious Diseases
mosquito
malaria
gene drive
efficacy
biosafety
MALARIA MOSQUITO
PROBLEM FORMULATION
ANOPHELES-GAMBIAE
TRANSMISSION
ELIMINATION
INFECTION
DYNAMICS
VECTORS
FITNESS
biosafety
efficacy
gene drive
malaria
mosquito
biosafety
efficacy
gene drive
malaria
mosquito
1117 Public Health and Health Services
Tropical Medicine
Publication Status: Published
Conference Place: United States
Online Publication Date: 2020-03-09
Appears in Collections:Faculty of Natural Sciences