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A 128 × 128 current-mode ultra-high frame rate ISFET array with in-pixel calibration for real-time ion imaging.

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Title: A 128 × 128 current-mode ultra-high frame rate ISFET array with in-pixel calibration for real-time ion imaging.
Authors: Zeng, J
Kuang, L
Miscourides, N
Georgiou, P
Item Type: Journal Article
Abstract: An ultra-high frame rate and high resolution ion-sensing Lab-on-Chip platform using a 128x128 CMOS ISFETarray is presented. Current mode operation is employed to facilitate high-speed operation, with the ISFET sensors biased in the triode region to provide a linear response. Sensing pixels include a reset switch to allow in pixel-calibration for nonidealities such as offset, trapped charge and drift by periodically resetting the floating gate of the ISFET sensor. Current mode row-parallel signal processing is applied throughout the readout pipeline including auto-zeroing circuits for the removal of fixed pattern noise. The 128 readout signals are multiplexed to eight high-sample-rate on-chip current mode ADCs followed by an off-chip PCIe-based digital readout system on a FPGA with a latency of 0.15s. Designed in a 0.35 um CMOS process, the complete system-on-chip occupies an area of 2.6mm x 2.2mm and the whole system achieves a frame rate of 3000fps which is the highest reported in the literature. The platform is demonstrated for real-time ion-imaging through the high-speed visualisation of sodium hydroxide (NaOH) diffusion in water. Furthermore, the proposed platform is able to achieve real-time visualisation of ion dynamics on a screen at 60fps in addition to slow-motion replay in 3000fps.
Issue Date: 12-Feb-2020
Date of Acceptance: 24-Jan-2020
URI: http://hdl.handle.net/10044/1/77424
DOI: 10.1109/TBCAS.2020.2973508
ISSN: 1932-4545
Publisher: Institute of Electrical and Electronics Engineers
Start Page: 359
End Page: 372
Journal / Book Title: IEEE Transactions on Biomedical Circuits and Systems
Volume: 14
Issue: 2
Copyright Statement: © 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Keywords: Science & Technology
Technology
Engineering, Biomedical
Engineering, Electrical & Electronic
Engineering
Current mode
in-pixel calibration
ISFET
linearity conversion
ultra-high frame rate
SENSOR
CMOS
CHIP
CALCIUM
DEVICE
LAB
0903 Biomedical Engineering
0906 Electrical and Electronic Engineering
Electrical & Electronic Engineering
Publication Status: Published online
Conference Place: United States
Online Publication Date: 2020-02-12
Appears in Collections:Electrical and Electronic Engineering
Faculty of Engineering