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Individually addressable multi-nanopores for single-molecule targeted operations

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Title: Individually addressable multi-nanopores for single-molecule targeted operations
Authors: Cadinu, P
Kang, M
Paulose Nadappuram, B
Ivanov, A
Edel, JB
Item Type: Journal Article
Abstract: The fine-tuning of molecular transport is a ubiquitous problem of single-molecule methods. The latter is evident even in powerful single-molecule methods such as nanopore sensing, where the quest for resolving more detailed biomolecular features is often limited by insufficient control of the dynamics of individual molecules within the detection volume of the nanopore. In this work, we introduce and characterize a reconfigurable multi-nanopore architecture that enables additional channels to manipulate the dynamics of DNA molecules in a nanopore. We show that the fabrication process of this device, consisting of four adjacent, individually addressable nanopores located at the tip of a quartz nanopipette, is fast and highly reproducible. By individually tuning the electric field across each nanopore, these devices can operate in several unique cooperative detection modes that allow moving, sensing, and trapping DNA molecules with high efficiency and increased temporal resolution.
Issue Date: 13-Feb-2020
Date of Acceptance: 13-Feb-2020
URI: http://hdl.handle.net/10044/1/76775
DOI: 10.1021/acs.nanolett.9b05307
ISSN: 1530-6984
Publisher: American Chemical Society (ACS)
Start Page: 2012
End Page: 2019
Journal / Book Title: Nano Letters
Volume: 20
Issue: 3
Copyright Statement: © 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano letters, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.9b05307
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Commission of the European Communities
Royal Society Of Chemistry
Funder's Grant Number: EP/P011985/1
724300
BB/R022429/1
875525
600322/05
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
single-molecule sensing multi-nanopore architecture
biophysics
nanopore sensing
DNA
biophysics
multi-nanopore architecture
nanopore sensing
single-molecule sensing
Nanoscience & Nanotechnology
Publication Status: Published online
Article Number: acs.nanolett.9b05307
Online Publication Date: 2020-02-13
Appears in Collections:Chemistry
Faculty of Natural Sciences