1
IRUS TotalDownloads
Altmetric
Individually addressable multi-nanopores for single-molecule targeted operations
File | Description | Size | Format | |
---|---|---|---|---|
2020_02_09_Quad multi_Clean.docx | Accepted version | 1.93 MB | Microsoft Word | View/Open |
Title: | Individually addressable multi-nanopores for single-molecule targeted operations |
Authors: | Cadinu, P Kang, M Paulose Nadappuram, B Ivanov, A Edel, JB |
Item Type: | Journal Article |
Abstract: | The fine-tuning of molecular transport is a ubiquitous problem of single-molecule methods. The latter is evident even in powerful single-molecule methods such as nanopore sensing, where the quest for resolving more detailed biomolecular features is often limited by insufficient control of the dynamics of individual molecules within the detection volume of the nanopore. In this work, we introduce and characterize a reconfigurable multi-nanopore architecture that enables additional channels to manipulate the dynamics of DNA molecules in a nanopore. We show that the fabrication process of this device, consisting of four adjacent, individually addressable nanopores located at the tip of a quartz nanopipette, is fast and highly reproducible. By individually tuning the electric field across each nanopore, these devices can operate in several unique cooperative detection modes that allow moving, sensing, and trapping DNA molecules with high efficiency and increased temporal resolution. |
Issue Date: | 13-Feb-2020 |
Date of Acceptance: | 13-Feb-2020 |
URI: | http://hdl.handle.net/10044/1/76775 |
DOI: | 10.1021/acs.nanolett.9b05307 |
ISSN: | 1530-6984 |
Publisher: | American Chemical Society (ACS) |
Start Page: | 2012 |
End Page: | 2019 |
Journal / Book Title: | Nano Letters |
Volume: | 20 |
Issue: | 3 |
Copyright Statement: | © 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano letters, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.9b05307 |
Sponsor/Funder: | Engineering & Physical Science Research Council (EPSRC) Commission of the European Communities Biotechnology and Biological Sciences Research Council (BBSRC) Commission of the European Communities Royal Society Of Chemistry |
Funder's Grant Number: | EP/P011985/1 724300 BB/R022429/1 875525 600322/05 |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics single-molecule sensing multi-nanopore architecture biophysics nanopore sensing DNA biophysics multi-nanopore architecture nanopore sensing single-molecule sensing Nanoscience & Nanotechnology |
Publication Status: | Published online |
Article Number: | acs.nanolett.9b05307 |
Online Publication Date: | 2020-02-13 |
Appears in Collections: | Chemistry Faculty of Natural Sciences |