IRUS Total

The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication

File Description SizeFormat 
1-s2.0-S0048733319302355-main.pdfPublished version3.41 MBAdobe PDFView/Open
Title: The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication
Authors: Cisnetto, V
Barlow, J
Item Type: Journal Article
Abstract: When there is significant uncertainty in an innovation project, research literature suggests that strictly sequencing actions and stages may not be an appropriate mode of project management. We use a longitudinal process approach and qualitative system dynamics modelling to study the development of genetically modified (GM) mosquitoes for malaria eradication in an African country. Our data were collected in real time, from early scientific research to deployment of the first prototype mosquitoes in the field. The 'gene drive' technology for modifying the mosquitoes is highly complex and controversial due to risks associated with its characteristics as a living, self-replicating technology. We show that in this case the innovation journey is linear and highly structured, but also embedded within a wider system of adoption that displays emergent behaviour. Although the need to control risks associated with the technology imposes a linearity to the NPD process, there are possibilities for deviation from a more structured sequence of stages. This arises from the effects of feedback loops in the wider system of evidence creation and learning at the population and governance levels, which cumulatively impact on acceptance of the innovation. The NPD and adoption processes are therefore closely intertwined, meaning that the endpoint for R&D and beginning of 'mainstream' adoption and diffusion are unclear. A key challenge for those responsible for NPD and its regulation is to plan for the adoption of the technology while simultaneously conducting its scientific and technical development.
Issue Date: 1-Apr-2020
Date of Acceptance: 23-Dec-2019
URI: http://hdl.handle.net/10044/1/76588
DOI: 10.1016/j.respol.2019.103917
ISSN: 0048-7333
Publisher: Elsevier
Journal / Book Title: Research Policy
Volume: 49
Issue: 3
Copyright Statement: © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
Keywords: New product development
Genetically modified mosquitoes
Living technology
Gene drive
Science Studies
1503 Business and Management
1402 Applied Economics
Publication Status: Published
Open Access location: https://www.sciencedirect.com/science/article/pii/S0048733319302355
Article Number: ARTN 103917
Online Publication Date: 2020-01-14
Appears in Collections:Imperial College Business School