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Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units

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Title: Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units
Authors: Chabloz, N
Perry, H
Yoon, I-C
Coulson, A
White, A
Stasiuk, G
Botnar, R
Wilton-Ely, J
Item Type: Journal Article
Abstract: A robust dithiocarbamate tether allows novel gadolinium units based on DOTAGA (q = 1) to be attached to the surface of gold nanoparticles (2.6 ‐ 4.1 nm diameter) along with functional units offering biocompatibility, targeting and photodynamic therapy. A dramatic increase in relaxivity (r1) per Gd unit from 5.01 mM−1 s−1 in unbound form to 31.68 mM−1 s−1 (10 MHz, 37 °C) is observed when immobilised on the surface due to restricted rotation and enhanced rigidity of the Gd complex on the nanoparticle surface. The single‐step synthetic route provides a straightforward and versatile way of preparing multifunctional gold nanoparticles, including examples with conjugated zinc‐tetraphenylporphyrin photosensitizers. The lack of toxicity of these materials (MTT assays) is transformed on irradiation of HeLa cells for 30 minutes (PDT), leading to 75% cell death. In addition to passive targeting, the inclusion of units capable of actively targeting overexpressed folate receptors illustrates the potential of these assemblies as targeted theranostic agents.
Issue Date: 6-Apr-2020
Date of Acceptance: 23-Jan-2020
URI: http://hdl.handle.net/10044/1/76438
DOI: 10.1002/chem.201904757
ISSN: 0947-6539
Publisher: Wiley
Start Page: 4552
End Page: 4566
Journal / Book Title: Chemistry – A European Journal
Volume: 26
Issue: 20
Copyright Statement: © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Chabloz, N., Perry, H., Yoon, I., Coulson, A., White, A., Stasiuk, G., Botnar, R. and Wilton-Ely, J. (2020), Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units. Chem. Eur. J.. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/chem.201904757
Sponsor/Funder: The Leverhulme Trust
Imperial College/Wellcome Trust Facility Network of Excellence scheme
Funder's Grant Number: RPG-2012-634
P52862
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
gadolinium
imaging agents
magnetic resonance imaging
nanoparticles
photodynamic therapy
FUNCTIONALIZED GOLD NANOPARTICLES
MULTIMETALLIC COMPLEXES
CONTRAST AGENTS
DITHIOCARBAMATE LIGANDS
STEPWISE GENERATION
QUANTUM DOTS
RELAXIVITY
NANORODS
CHELATE
ARRAYS
gadolinium
imaging agents
magnetic resonance imaging
nanoparticles
photodynamic therapy
General Chemistry
03 Chemical Sciences
Publication Status: Published
Article Number: chem.201904757
Online Publication Date: 2020-01-25
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Grantham Institute for Climate Change
Faculty of Natural Sciences