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Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae

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Title: Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae
Authors: Dewe, TCM
D'Aetht, JC
Croucher, NJ
Item Type: Journal Article
Abstract: Penicillin-non-susceptible Streptococcus pneumoniae (PNSP) were first detected in the 1960s, and are now common worldwide, predominantly through the international spread of a limited number of strains. Extant PNSP are characterized by mosaic pbp2x, pbp2b and pbp1a genes generated by interspecies recombinations, with the extent of these alterations determining the range and concentrations of β-lactams to which the genotype is non-susceptible. The complexity of the genetics underlying these phenotypes has been the subject of both molecular microbiology and genome-wide association and epistasis analyses. Such studies can aid our understanding of PNSP evolution and help improve the already highly-performing bioinformatic methods capable of identifying PNSP from genomic surveillance data.
Issue Date: 1-Oct-2019
Date of Acceptance: 19-Sep-2019
URI: http://hdl.handle.net/10044/1/75997
DOI: 10.1099/mgen.0.000305
ISSN: 2057-5858
Publisher: Microbiology Society
Start Page: 1
End Page: 8
Journal / Book Title: Microbial Genomics
Volume: 5
Issue: 10
Copyright Statement: © 2019 The Authors This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/R015600/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Microbiology
antibiotic resistance
pneumococcus
genomic epidemiology
penicillin
BINDING PROTEIN GENES
ANTIBIOTIC USE
BETA-LACTAM
RISK-FACTORS
CONJUGATE VACCINE
RESISTANT PNEUMOCOCCI
HORIZONTAL TRANSFER
UNITED-STATES
CARRIAGE
EVOLUTION
antibiotic resistance
genomic epidemiology
penicillin
pneumococcus
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Microbiology
antibiotic resistance
pneumococcus
genomic epidemiology
penicillin
BINDING PROTEIN GENES
ANTIBIOTIC USE
BETA-LACTAM
RISK-FACTORS
CONJUGATE VACCINE
RESISTANT PNEUMOCOCCI
HORIZONTAL TRANSFER
UNITED-STATES
CARRIAGE
EVOLUTION
Publication Status: Published
Article Number: ARTN 000305
Online Publication Date: 2019-10-14
Appears in Collections:School of Public Health