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A MnO2 nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells

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Li et al, ACS Nano 2019, accepted manuscript.pdfAccepted version8.12 MBAdobe PDFView/Open
Li et al, ACS Nano, supporting information.pdfSupporting information5.83 MBAdobe PDFView/Open
Title: A MnO2 nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells
Authors: Li, L
Xiao, B
Mu, J
Zhang, Y
Zhang, C
Cao, H
Chen, R
Patra, HK
Yang, B
Feng, S
Tabata, Y
Slater, NKH
Tang, J
Shen, Y
Gao, J
Item Type: Journal Article
Abstract: Spinal cord injury (SCI) is one of the most debilitating injuries and transplantation of stem cells in a scaffold is a promising strategy for the treatment. However, the stem cell treatment of SCI has been severely impaired by the increased generation of reactive oxygen species in the lesion microenvironment, which can lead to a high level of stem cell death and dysfunction. Herein, a MnO2 nanoparticle (NP)-dotted hydrogel is prepared through dispersion of MnO2 NPs in a PPFLMLLKGSTR peptide modified hyaluronic acid hydrogel. The peptide modified hydrogel enables the adhesive growth of mesenchymal stem cells (MSCs) and nerve tissue bridging. The MnO2 NPs alleviate the oxidative environment, thereby effectively improving the viability of MSCs. Transplantation of MSCs in the multifunctional gel generates a significant motor function restoration on a long-span rat spinal cord transection model and induces an in vivo integration as well as neural differentiation of the implanted MSCs, leading to a highly efficient regeneration of central nervous spinal cord tissue. Therefore, the MnO2 NP-dotted hydrogel represents a promising strategy for stem cell-based therapies of central nervous system diseases through the comprehensive regulation of pathological microenvironment complications.
Issue Date: 24-Dec-2019
Date of Acceptance: 26-Nov-2019
URI: http://hdl.handle.net/10044/1/75417
DOI: 10.1021/acsnano.9b07598
ISSN: 1936-0851
Publisher: American Chemical Society (ACS)
Start Page: 14283
End Page: 14293
Journal / Book Title: ACS Nano
Volume: 13
Issue: 12
Copyright Statement: © 2019 American Chemical Society
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
manganese dioxide nanoparticle
reactive oxygen species
hydrogel scaffold
mesenchymal stem cells
spinal cord injury
HYALURONIC-ACID
ALBUMIN-MNO2 NANOPARTICLES
NEURAL-NETWORK
RECOVERY
TRANSPLANTATION
TRANSECTION
ADHESIONS
SCAFFOLD
HYPOXIA
GROWTH
hydrogel scaffold
manganese dioxide nanoparticle
mesenchymal stem cells
reactive oxygen species
spinal cord injury
Nanoscience & Nanotechnology
Publication Status: Published
Online Publication Date: 2019-11-26
Appears in Collections:Chemical Engineering
Faculty of Engineering