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Obesity affects graft function but not graft loss in kidney transplant recipients

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Title: Obesity affects graft function but not graft loss in kidney transplant recipients
Authors: Bellini, MI
Koutroustos, K
Nanapragasam, H
Deurloo, E
Galliford, J
Herbert, P
Item Type: Journal Article
Abstract: Background: There is an ongoing debate regarding the suitability for transplantation of the high Body Mass Index (BMI) kidney transplant recipients (KTRs). Methods: Retrospective analysis of 370 consecutive KTRs stratified according to the World Health Organisation Body Mass Index categories. As a measure of allograft function eGFR was used. Results: Mean BMI was 26.2: 148 (40%) pre-obese, 47 (12.7%) class I obese, 11 (3%) class II obese, 9 (2.4%) class III obese. A linear trend from the normal BMI group moving through the progressively higher groups was observed for male sex and younger age. Overweight and obese KTRs had higher incidence of pre-transplant diabetes (P = 0.021), but there was no difference in new-onset hyperglycemia post-transplant (P = 0.35). Obesity was not a significant risk factor for lower eGFR at 1 year follow-up, but it became at 2 and 3 years follow up. No statistical difference in Delayed Graft Function and hospital length of stay was observed. 28 patients lost their grafts, and 25 patients died during follow-up. Kaplan-Meier analysis showed no difference in all-cause allograft loss between the different BMI groups (log rank P = 0.8) in a mean follow-up of 42 months (0-58). Conclusion: Obesity affects eGFR in the long-term. The allograft survival was lower but not significant.
Date of Acceptance: 25-Nov-2019
URI: http://hdl.handle.net/10044/1/75395
DOI: 10.1177/0300060519895139
ISSN: 0300-0605
Publisher: SAGE Publications (UK and US)
Start Page: 1
End Page: 9
Journal / Book Title: Journal of International Medical Research
Volume: 48
Issue: 1
Copyright Statement: © The Author(s) 2020. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Obesity
bariatric surgery
body mass index
estimated glomerular filtration rate
kidney function
kidney transplant
General & Internal Medicine
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2020-01-15
Appears in Collections:Faculty of Medicine