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Remote magnetic nanoparticle manipulation enables the dynamic patterning of cardiac tissues

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Title: Remote magnetic nanoparticle manipulation enables the dynamic patterning of cardiac tissues
Authors: Zwi Dantsis, L
Wang, B
Marijon, C
Zonetti, S
Ferrini, A
Massi, L
Stuckey, DJ
Terracciano, C
Stevens, M
Item Type: Journal Article
Abstract: The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, we develop a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3-dimensional (3D) collagen hydrogels to dynamically create various tailored microstructures of cardiac tissues. This isachieved by incorporating iron-oxide nanoparticles into human cardiomyocytes (CMs) and applying a short-term external magnetic field to orient the cells along the applied field to impart different shapes without any mechanical supports. The patterned constructs areviable and functional, canbe detected by T2*-weighted MRI and induceno alteration to normal cardiac function after grafting onto rat hearts. This strategy paves the way to creating customized, macroscale, 3D tissue constructs with various cell-types for therapeutic and bioengineering applications, as well as providing powerful models for investigating tissue behavior.
Issue Date: 13-Feb-2020
Date of Acceptance: 21-Nov-2019
URI: http://hdl.handle.net/10044/1/75337
DOI: 10.1002/adma.201904598
ISSN: 0935-9648
Publisher: Wiley
Start Page: 1
End Page: 6
Journal / Book Title: Advanced Materials
Volume: 32
Issue: 6
Copyright Statement: © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Commission of the European Communities
Medical Research Council (MRC)
British Heart Foundation
British Heart Foundation
Wellcome Trust
Kusuma Trust UK
British Heart Foundation
Funder's Grant Number: 659175
MR/R015651/1
RE/13/4/30184
RM/13/1/30157
098411/Z/12/Z
MMRE_P74027
FS/10/47/28393
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
cardiac tissues
cellular organization
hydrogels
magnetic nanoparticles
patterning
ENGINEERED HEART-TISSUE
PLATFORM
MUSCLE
MYOCARDIUM
CELLS
FIELD
CHIP
cardiac tissues
cellular organization
hydrogels
magnetic nanoparticles
patterning
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Nanoscience & Nanotechnology
Publication Status: Published
Online Publication Date: 2019-12-13
Appears in Collections:Materials
National Heart and Lung Institute
Faculty of Natural Sciences
Faculty of Engineering